BACKGROUND: Psoriasis is a chronic skin disease characterized by epithelial hyperplasia and an accelerated rate of epithelial turnover affecting approximately 1-3% of the population. Exogenous and endogenous factors including morbid obesity can increase the morbidity of psoriasis. CASE REPORT: A 55-year-old male, who weighed 131 kg with BMI 41 kg/m2, underwent laparoscopic Roux-en-Y gastric bypass (LRYGBP). He had a 15-year duration of severe psoriasis and was being medically treated. At 12 months after LRYGBP, he had lost 39 kg (68% EWL), and had complete resolution of the psoriasis and had discontinued all preoperative medications related to the disease. At 2 years after LRYGBP, psoriasis has not recurred. CONCLUSION: Weight loss after LRYGBP should be considered as a strategy in the treatment of severe psoriasis in morbidly obese patients.
BACKGROUND:Psoriasis is a chronic skin disease characterized by epithelial hyperplasia and an accelerated rate of epithelial turnover affecting approximately 1-3% of the population. Exogenous and endogenous factors including morbid obesity can increase the morbidity of psoriasis. CASE REPORT: A 55-year-old male, who weighed 131 kg with BMI 41 kg/m2, underwent laparoscopic Roux-en-Y gastric bypass (LRYGBP). He had a 15-year duration of severe psoriasis and was being medically treated. At 12 months after LRYGBP, he had lost 39 kg (68% EWL), and had complete resolution of the psoriasis and had discontinued all preoperative medications related to the disease. At 2 years after LRYGBP, psoriasis has not recurred. CONCLUSION:Weight loss after LRYGBP should be considered as a strategy in the treatment of severe psoriasis in morbidly obesepatients.
Authors: A Johnston; S Arnadottir; J E Gudjonsson; A Aphale; A A Sigmarsdottir; S I Gunnarsson; J T Steinsson; J T Elder; H Valdimarsson Journal: Br J Dermatol Date: 2008-06-28 Impact factor: 9.302
Authors: Amy S Paller; Katherine Mercy; Mary J Kwasny; Siew Eng Choon; Kelly M Cordoro; Giampiero Girolomoni; Alan Menter; Wynnis L Tom; Anne M Mahoney; Annet M Oostveen; Marieke M B Seyger Journal: JAMA Dermatol Date: 2013-02 Impact factor: 10.282
Authors: Alexa B Kimball; Dafna Gladman; Joel M Gelfand; Kenneth Gordon; Elizabeth J Horn; Neil J Korman; Gretchen Korver; Gerald G Krueger; Bruce E Strober; Mark G Lebwohl Journal: J Am Acad Dermatol Date: 2008-03-04 Impact factor: 11.527