BACKGROUND: In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required. METHODS: These values are available from baseline levels in animals subjected to tolerability/pharmacokinetic studies. For each individual study two tests for clinical chemistry and hematology were performed before the start of treatment. RESULTS AND CONCLUSION: We present such data from 17 male and 16 female baboons, with body weights ranging between 4.4 and 14.0 kg (males) and 4.1 and 15.0 kg (females), respectively. The number of duplicate samples per animal determined before each individual study ranged between one and five. These data are reported here to provide baseline values for veterinarians and investigators using baboons in experimental studies, particularly in xenotransplantation.
BACKGROUND: In vivo xenotransplantation modeling in large animal species is often performed in nonhuman primates, including baboons. For proper data interpretation, reference values for clinical chemistry and hematology are required. METHODS: These values are available from baseline levels in animals subjected to tolerability/pharmacokinetic studies. For each individual study two tests for clinical chemistry and hematology were performed before the start of treatment. RESULTS AND CONCLUSION: We present such data from 17 male and 16 female baboons, with body weights ranging between 4.4 and 14.0 kg (males) and 4.1 and 15.0 kg (females), respectively. The number of duplicate samples per animal determined before each individual study ranged between one and five. These data are reported here to provide baseline values for veterinarians and investigators using baboons in experimental studies, particularly in xenotransplantation.
Authors: Burcin Ekser; John Bianchi; Suyapa Ball; Hayato Iwase; Anneke Walters; Mohamed Ezzelarab; Massimiliano Veroux; Bruno Gridelli; Robert Wagner; David Ayares; David K C Cooper Journal: Xenotransplantation Date: 2012-11-12 Impact factor: 3.907
Authors: Nicolas Poirier; Agnes M Azimzadeh; Tianshu Zhang; Nahzli Dilek; Caroline Mary; Bao Nguyen; Xavier Tillou; Guosheng Wu; Karine Reneaudin; Jeremy Hervouet; Bernard Martinet; Flora Coulon; Emma Allain-Launay; Georges Karam; Jean-Paul Soulillou; Richard N Pierson; Gilles Blancho; Bernard Vanhove Journal: Sci Transl Med Date: 2010-02-03 Impact factor: 17.956
Authors: Hayato Iwase; Burcin Ekser; Hao Zhou; Eefje M Dons; David K C Cooper; Mohamed B Ezzelarab Journal: Xenotransplantation Date: 2012 Jul-Aug Impact factor: 3.907