Literature DB >> 1547888

Sequence-specific resonance assignment and conformational analysis of subtilin by 2D NMR.

W C Chan1, B W Bycroft, M L Leyland, L Y Lian, J C Yang, G C Roberts.   

Abstract

Subtilin, a 32-amino acid peptide with potent antimicrobial activity, has been isolated from Bacillus subtilis ATCC6633. The chemical structure has been confirmed by the unambiguous sequence-specific assignment of its 1H NMR spectrum. Detailed NMR analysis revealed that subtilin is a rather flexible molecule; the only observed conformational contraints were those imposed by the cyclic structures created by the lanthionine and 3-methyllanthionine residues. These results suggest that in aqueous solution subtilin and the homologous peptide nisin have similar conformations.

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Year:  1992        PMID： 1547888     DOI： 10.1016/0014-5793(92)80163-b

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

Review 1.  Structures of lantibiotics studied by NMR.

Authors:  F J van De Ven; G Jung
Journal:  Antonie Van Leeuwenhoek       Date:  1996-02       Impact factor: 2.271

2.  Structure-activity relationships in the peptide antibiotic nisin: role of dehydroalanine 5.

Authors:  W C Chan; H M Dodd; N Horn; K Maclean; L Y Lian; B W Bycroft; M J Gasson; G C Roberts
Journal:  Appl Environ Microbiol       Date:  1996-08       Impact factor: 4.792

Review 3.  Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes.

Authors:  Lindsay M Repka; Jonathan R Chekan; Satish K Nair; Wilfred A van der Donk
Journal:  Chem Rev       Date:  2017-01-30       Impact factor: 60.622

4.  The Clostridium difficile cpr locus is regulated by a noncontiguous two-component system in response to type A and B lantibiotics.

Authors:  Jose M Suárez; Adrianne N Edwards; Shonna M McBride
Journal:  J Bacteriol       Date:  2013-03-29       Impact factor: 3.490

5.  Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.

Authors:  Feifei Zhang; Wendy L Kelly
Journal:  ACS Chem Biol       Date:  2015-01-20       Impact factor: 5.100

6.  A novel post-translational modification of the peptide antibiotic subtilin: isolation and characterization of a natural variant from Bacillus subtilis A.T.C.C. 6633.

Authors:  W C Chan; B W Bycroft; M L Leyland; L Y Lian; G C Roberts
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

7.  Exploring structural signatures of the lanthipeptide prochlorosin 2.8 using tandem mass spectrometry and trapped ion mobility-mass spectrometry.

Authors:  Kevin Jeanne Dit Fouque; Julian D Hegemann; Miguel Santos-Fernandez; Tung T Le; Mario Gomez-Hernandez; Wilfred A van der Donk; Francisco Fernandez-Lima
Journal:  Anal Bioanal Chem       Date:  2021-06-08       Impact factor: 4.478

8.  A Chemical Biology Approach to Understanding Molecular Recognition of Lipid II by Nisin(1-12): Synthesis and NMR Ensemble Analysis of Nisin(1-12) and Analogues.

Authors:  Rachael Dickman; Emma Danelius; Serena A Mitchell; D Flemming Hansen; Máté Erdélyi; Alethea B Tabor
Journal:  Chemistry       Date:  2019-10-10       Impact factor: 5.236

9.  Isolation, Characterization and Structure Elucidation of a Novel Lantibiotic From Paenibacillus sp.

Authors:  Jerzy Karczewski; Stephen P Krasucki; Papa Nii Asare-Okai; Carl Diehl; Andrew Friedman; Christine M Brown; Yukari Maezato; Stephen J Streatfield
Journal:  Front Microbiol       Date:  2020-11-24       Impact factor: 5.640
  9 in total

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