OBJECTIVE: To assess the usefulness of measuring serum matrix metalloproteinase 3 (MMP-3) and macrophage colony-stimulating factor (M-CSF) in patients with ankylosing spondylitis (AS). METHODS: Serum levels of MMP-3 and M-CSF were measured in AS patients who did and did not receive infliximab treatment. These were compared with those of 28 healthy subjects. RESULTS: In the group of AS patients not treated with biologics, both M-CSF and MMP-3 correlated with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) values, but not with each other. Logistic regression analysis showed that MMP-3 values were high in those with severely active disease. Infusions of infliximab in AS patients led to a significant decrease in the values of the BASDAI as well as the serum MMP-3, but no change in the serum M-CSF values. CONCLUSION: MMP-3 and M-CSF are potentially useful markers of AS disease activity.
OBJECTIVE: To assess the usefulness of measuring serum matrix metalloproteinase 3 (MMP-3) and macrophage colony-stimulating factor (M-CSF) in patients with ankylosing spondylitis (AS). METHODS: Serum levels of MMP-3 and M-CSF were measured in AS patients who did and did not receive infliximab treatment. These were compared with those of 28 healthy subjects. RESULTS: In the group of AS patients not treated with biologics, both M-CSF and MMP-3 correlated with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) values, but not with each other. Logistic regression analysis showed that MMP-3 values were high in those with severely active disease. Infusions of infliximab in AS patients led to a significant decrease in the values of the BASDAI as well as the serum MMP-3, but no change in the serum M-CSF values. CONCLUSION:MMP-3 and M-CSF are potentially useful markers of AS disease activity.
Authors: M Rihl; E Kruithof; C Barthel; F De Keyser; E M Veys; H Zeidler; D T Y Yu; J G Kuipers; D Baeten Journal: Ann Rheum Dis Date: 2005-04-07 Impact factor: 19.103
Authors: Hideki Kitaura; Ping Zhou; Hyun-Ju Kim; Deborah V Novack; F Patrick Ross; Steven L Teitelbaum Journal: J Clin Invest Date: 2005-11-17 Impact factor: 14.808
Authors: Consuelo Romero-Sánchez; William H Robinson; Beren H Tomooka; John Londoño; Rafael Valle-Oñate; Feng Huang; Xiaohu Deng; Liyun Zhang; Chunhua Yang; David Tak Yan Yu Journal: Clin Rheumatol Date: 2008-06-20 Impact factor: 2.980