| Literature DB >> 15478069 |
Liza Bornman1, Sarah J Campbell, Katherine Fielding, Boubacar Bah, Jackson Sillah, Per Gustafson, Kebba Manneh, Ida Lisse, Angela Allen, Giorgio Sirugo, Aissatou Sylla, Peter Aaby, Keith P W J McAdam, Oumou Bah-Sow, Steve Bennett, Christian Lienhardt, Adrian V S Hill.
Abstract
Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.Entities:
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Year: 2004 PMID： 15478069 DOI： 10.1086/424462
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226