| Literature DB >> 15477554 |
I Rainero1, S Gallone, W Valfrè, M Ferrero, G Angilella, C Rivoiro, E Rubino, P De Martino, L Savi, M Ferrone, L Pinessi.
Abstract
Several polymorphisms of the hypocretin/orexin system genes were evaluated in 109 cluster headache patients and 211 controls. The 1246 G>A polymorphism of the gene was significantly different between cases and controls. Homozygosity for the G allele was associated with an increased disease risk (OR: 6.79, 95% CI, 2.25 to 22.99). The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache.Entities:
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Year: 2004 PMID： 15477554 DOI： 10.1212/01.wnl.0000142424.65251.db
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910