OBJECTIVE: To study the association between white matter lesions (WML) in specific locations and the risk of dementia. DESIGN: The Rotterdam Scan Study, a prospective population-based cohort study. We scored periventricular and subcortical WML on magnetic resonance imaging and observed participants until January 2002 for incident dementia. SETTING: General population. PARTICIPANTS: We included 1077 people aged 60 to 90 years who did not have dementia at baseline. MAIN OUTCOME MEASURE: Incident dementia by Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM III-R) criteria. RESULTS: During a mean follow-up of 5.2 years, 45 participants developed dementia. Higher severity of periventricular WML increased the risk of dementia, whereas the association between subcortical WML and dementia was less prominent. The adjusted hazard ratio of dementia for each standard deviation increase in periventricular WML severity was 1.67 (95% confidence interval, 1.25-2.24). This increased risk was independent of other risk factors for dementia and partly independent of other structural brain changes on magnetic resonance imaging. CONCLUSION: White matter lesions, especially in the periventricular region, increase the risk of dementia in elderly people.
OBJECTIVE: To study the association between white matter lesions (WML) in specific locations and the risk of dementia. DESIGN: The Rotterdam Scan Study, a prospective population-based cohort study. We scored periventricular and subcortical WML on magnetic resonance imaging and observed participants until January 2002 for incident dementia. SETTING: General population. PARTICIPANTS: We included 1077 people aged 60 to 90 years who did not have dementia at baseline. MAIN OUTCOME MEASURE: Incident dementia by Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM III-R) criteria. RESULTS: During a mean follow-up of 5.2 years, 45 participants developed dementia. Higher severity of periventricular WML increased the risk of dementia, whereas the association between subcortical WML and dementia was less prominent. The adjusted hazard ratio of dementia for each standard deviation increase in periventricular WML severity was 1.67 (95% confidence interval, 1.25-2.24). This increased risk was independent of other risk factors for dementia and partly independent of other structural brain changes on magnetic resonance imaging. CONCLUSION:White matter lesions, especially in the periventricular region, increase the risk of dementia in elderly people.
Authors: C E Shaaban; H J Aizenstein; D R Jorgensen; R L MacCloud; N A Meckes; K I Erickson; N W Glynn; J Mettenburg; J Guralnik; A B Newman; T S Ibrahim; P J Laurienti; A N Vallejo; C Rosano Journal: AJNR Am J Neuroradiol Date: 2017-08-03 Impact factor: 3.825
Authors: N Amin; O Jovanova; H H H Adams; A Dehghan; M Kavousi; M W Vernooij; R P Peeters; F M S de Vrij; S J van der Lee; J G J van Rooij; E M van Leeuwen; L Chaker; A Demirkan; A Hofman; R W W Brouwer; R Kraaij; K Willems van Dijk; T Hankemeier; W F J van Ijcken; A G Uitterlinden; W J Niessen; O H Franco; S A Kushner; M A Ikram; H Tiemeier; C M van Duijn Journal: Mol Psychiatry Date: 2016-07-19 Impact factor: 15.992
Authors: Lina Bergman; Pablo Torres-Vergara; Jeffrey Penny; Johan Wikström; Maria Nelander; Jose Leon; Mary Tolcher; James M Roberts; Anna-Karin Wikström; Carlos Escudero Journal: Curr Hypertens Rep Date: 2019-08-02 Impact factor: 5.369
Authors: Swati Rane; Julia Owen; Daniel S Hippe; Brenna Cholerton; Cyrus P Zabetian; Tom Montine; Thomas J Grabowski Journal: J Neuroimaging Date: 2020-09-16 Impact factor: 2.486
Authors: D H Salat; D S Tuch; A J W van der Kouwe; D N Greve; V Pappu; S Y Lee; N D Hevelone; A K Zaleta; J H Growdon; S Corkin; B Fischl; H D Rosas Journal: Neurobiol Aging Date: 2010-02 Impact factor: 4.673
Authors: Frank A Provenzano; Jordan Muraskin; Giuseppe Tosto; Atul Narkhede; Ben T Wasserman; Erica Y Griffith; Vanessa A Guzman; Irene B Meier; Molly E Zimmerman; Adam M Brickman Journal: JAMA Neurol Date: 2013-04 Impact factor: 18.302
Authors: Lisa C Silbert; Hiroko H Dodge; Louie G Perkins; Lena Sherbakov; David Lahna; Deniz Erten-Lyons; Randall Woltjer; Lynne Shinto; Jeffrey A Kaye Journal: Neurology Date: 2012-07-25 Impact factor: 9.910