BACKGROUND: In patients with ischemic cardiomyopathy, left ventricular (LV) remodeling is an important prognostic indicator. The precise relation between viable myocardium, revascularization, and ongoing or reversed remodeling is unknown and was evaluated in the present study. METHODS AND RESULTS: A total of 100 patients with ischemic cardiomyopathy underwent dobutamine stress echocardiography to assess myocardial viability and LV geometry (volumes and shape). At a mean of 10.2 months and 4.5 years after revascularization, resting echocardiography was repeated to evaluate LV remodeling. Long-term follow-up (mean 5+/-2 years) data were obtained. According to dobutamine stress echocardiography, 44 patients (44%) were defined as viable (> or =4 viable segments) and 56 as nonviable. After revascularization, 40 patients (43%) had ongoing LV remodeling and 53 (57%) did not (in 7 patients who died early after revascularization, postoperative echocardiographic evaluation was not available). On multivariable analysis, the number of viable segments was the only predictor of ongoing LV remodeling (OR 0.60, 95% CI 0.48 to 0.75; P<0.0001). The likelihood of LV remodeling decreased as the number of viable segments increased. During the follow-up, reverse remodeling was present in viable patients, whereas in nonviable patients, LV volumes significantly increased, which indicates ongoing LV remodeling. At follow-up, viable patients also showed a persistent improvement of heart failure symptoms and fewer cardiac events than nonviable patients (P<0.05). CONCLUSIONS: In patients with ischemic cardiomyopathy, a substantial amount of viable myocardium prevents ongoing LV remodeling after revascularization and is associated with persistent improvement of symptoms and better outcome.
BACKGROUND: In patients with ischemic cardiomyopathy, left ventricular (LV) remodeling is an important prognostic indicator. The precise relation between viable myocardium, revascularization, and ongoing or reversed remodeling is unknown and was evaluated in the present study. METHODS AND RESULTS: A total of 100 patients with ischemic cardiomyopathy underwent dobutamine stress echocardiography to assess myocardial viability and LV geometry (volumes and shape). At a mean of 10.2 months and 4.5 years after revascularization, resting echocardiography was repeated to evaluate LV remodeling. Long-term follow-up (mean 5+/-2 years) data were obtained. According to dobutamine stress echocardiography, 44 patients (44%) were defined as viable (> or =4 viable segments) and 56 as nonviable. After revascularization, 40 patients (43%) had ongoing LV remodeling and 53 (57%) did not (in 7 patients who died early after revascularization, postoperative echocardiographic evaluation was not available). On multivariable analysis, the number of viable segments was the only predictor of ongoing LV remodeling (OR 0.60, 95% CI 0.48 to 0.75; P<0.0001). The likelihood of LV remodeling decreased as the number of viable segments increased. During the follow-up, reverse remodeling was present in viable patients, whereas in nonviable patients, LV volumes significantly increased, which indicates ongoing LV remodeling. At follow-up, viable patients also showed a persistent improvement of heart failure symptoms and fewer cardiac events than nonviable patients (P<0.05). CONCLUSIONS: In patients with ischemic cardiomyopathy, a substantial amount of viable myocardium prevents ongoing LV remodeling after revascularization and is associated with persistent improvement of symptoms and better outcome.
Authors: Emer Joyce; Darryl P Leong; Georgette E Hoogslag; Paul L van Herck; Philippe Debonnaire; Elena Abate; Eduard R Holman; Martin J Schalij; Jeroen J Bax; Victoria Delgado; Nina Ajmone Marsan Journal: Int J Cardiovasc Imaging Date: 2013-12-19 Impact factor: 2.357
Authors: Tammy J Pegg; Joseph B Selvanayagam; Joslin Jennifer; Jane M Francis; Theodoros D Karamitsos; Erica Dall'Armellina; Karen L Smith; David P Taggart; Stefan Neubauer Journal: J Cardiovasc Magn Reson Date: 2010-10-07 Impact factor: 5.364
Authors: Dipan J Shah; Han W Kim; Olga James; Michele Parker; Edwin Wu; Robert O Bonow; Robert M Judd; Raymond J Kim Journal: JAMA Date: 2013-03-06 Impact factor: 56.272
Authors: Domenico D'Amario; Antonio M Leone; Antonio Iaconelli; Nicola Luciani; Mario Gaudino; Ramaswamy Kannappan; Melissa Manchi; Anna Severino; Sang Hun Shin; Francesca Graziani; Gina Biasillo; Andrea Macchione; Costantino Smaldone; Giovanni Luigi De Maria; Carlo Cellini; Andrea Siracusano; Lara Ottaviani; Massimo Massetti; Polina Goichberg; Annarosa Leri; Piero Anversa; Filippo Crea Journal: Circulation Date: 2013-11-18 Impact factor: 29.690
Authors: Christos V Bourantas; Nikolay P Nikitin; Huan P Loh; Elena I Lukaschuk; Nassar Sherwi; Ramesh de Silva; Ann C Tweddel; Mohamed F Alamgir; Kenneth Wong; Sanjay Gupta; Andrew L Clark; John Gf Cleland Journal: J Cardiovasc Magn Reson Date: 2011-09-21 Impact factor: 5.364