| Literature DB >> 15476945 |
Takanobu Yoshimoto1, Mika Matsushita, Yukio Hirata.
Abstract
Urotensin II (UII), originally isolated from goby urophysis, has been shown to be an endogenous ligand for an orphan G-protein-coupled receptor, GPR14. Recent development of PCR quantitative method revealed that UII and UT receptor (GPR14) were expressed in a broad range of tissues and organs, including cardiovascular and renal system, and assumed to function as an autocrine/paracrine factor. UII is a potent vasoconstrictor peptide, whose potency is greater than any other vasoconstrictors thus far known. However, its physiological roles have been found to extend far beyond the regulation of vascular tone. In this review, we focused on the mitogenic action of UII and discuss its underlying cellular mechanisms and potential physiological/pathophysiological role in various human diseases.Entities:
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Year: 2004 PMID： 15476945 DOI： 10.1016/j.peptides.2004.03.028
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750