| Literature DB >> 15476630 |
Daisuke Jitsuiki1, Yukihito Higashi, Chikara Goto, Masashi Kimura, Kensuke Noma, Keiko Hara, Keigo Nakagawa, Tetsuya Oshima, Kazuaki Chayama, Masao Yoshizumi.
Abstract
The forearm blood flow (FBF) responses to acetylcholine and to sodium nitroprusside were evaluated before and after administration of edaravone in 10 smokers and 10 nonsmokers. FBF response to acetylcholine was lower in smokers than in nonsmokers. The vasodilatory effects of sodium nitroprusside were similar in both groups. Co-infusion of edaravone increased the FBF response to acetylcholine in smokers, but did not affect the FBF response to acetylcholine in nonsmokers. The administration of N(G)-monomethyl-l-arginine abolished edaravone-induced augmentation of the FBF response to acetylcholine in smokers. The antioxidative agent edaravone increases nitric oxide mediated vasodilation through a decrease in oxidative stress.Entities:
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Year: 2004 PMID： 15476630 DOI： 10.1016/j.amjcard.2004.06.072
Source DB: PubMed Journal: Am J Cardiol ISSN： 0002-9149 Impact factor: 2.778