Hypothalamic control of body temperature: insights from the past.

This essay looks at the historical significance of three APS classic papers that are freely available online: Hammel HT, Hardy JD, and Fusco MM. Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs. Am J Physiol 198: 481-486, 1960 (http://ajplegacy.physiology.org/cgi/reprint/198/3/481). Hammel HT, Jackson DC, Stolwijk JAJ, Hardy JD, and Stromme SB. Temperature regulation by hypothalamic proportional control with an adjustable set point. J Appl Physiol 18: 1146-1154, 1963 (http://jap.physiology.org/cgi/reprint/18/6/1146). Hellstrom B and Hammel HT. Some characteristics of temperature regulation in the unanesthetized dog. Am J Physiol 213: 547-556, 1967 (http://ajplegacy.physiology.org/cgi/reprint/213/2/547). Copyright 2004 American Physiological Society