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Literature DB >> 15475110

Analysis of the centromeric regions of the human genome assembly.

M Katharine Rudd¹, Huntington F Willard.

Abstract

The sequence of the human genome is not yet complete, and major gaps remain at the centromere region of each chromosome, which is comprised of repetitive alpha satellite DNA. In this article, we describe the sequences in the vicinity of the centromere that are included in the current genome assembly, analyze the approximately 7Mb of alpha satellite that have been assembled thus far and anticipate the nature of the sequences that remain to be accounted for.

Entities: Species

Mesh：

Substances：
DNA, Satellite

Year: 2004 PMID： 15475110 DOI： 10.1016/j.tig.2004.08.008

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

98 in total

1. Tripartite organization of centromeric chromatin in budding yeast.

Authors: Kristina Krassovsky; Jorja G Henikoff; Steven Henikoff
Journal: Proc Natl Acad Sci U S A Date: 2011-12-19 Impact factor: 11.205

Review 2. Centromeres of filamentous fungi.

Authors: Kristina M Smith; Jonathan M Galazka; Pallavi A Phatale; Lanelle R Connolly; Michael Freitag
Journal: Chromosome Res Date: 2012-07 Impact factor: 5.239

3. Genome-wide characterization of centromeric satellites from multiple mammalian genomes.

Authors: Can Alkan; Maria Francesca Cardone; Claudia Rita Catacchio; Francesca Antonacci; Stephen J O'Brien; Oliver A Ryder; Stefania Purgato; Monica Zoli; Giuliano Della Valle; Evan E Eichler; Mario Ventura
Journal: Genome Res Date: 2010-11-16 Impact factor: 9.043

4. Large tandem, higher order repeats and regularly dispersed repeat units contribute substantially to divergence between human and chimpanzee Y chromosomes.

Authors: Vladimir Paar; Matko Glunčić; Ivan Basar; Marija Rosandić; Petar Paar; Mislav Cvitković
Journal: J Mol Evol Date: 2010-11-20 Impact factor: 2.395

Analysis of the centromeric regions of the human genome assembly.

1. Tripartite organization of centromeric chromatin in budding yeast.

Review 2. Centromeres of filamentous fungi.

3. Genome-wide characterization of centromeric satellites from multiple mammalian genomes.

4. Large tandem, higher order repeats and regularly dispersed repeat units contribute substantially to divergence between human and chimpanzee Y chromosomes.

Review 5. Completing the human genome: the progress and challenge of satellite DNA assembly.

6. Clusters of alpha satellite on human chromosome 21 are dispersed far onto the short arm and lack ancient layers.

7. Interchromosomal segmental duplications of the pericentromeric region on the human Y chromosome.

Review 8. Artificial and engineered chromosomes: developments and prospects for gene therapy.

9. The evolutionary dynamics of alpha-satellite.

10. Progressive proximal expansion of the primate X chromosome centromere.