Literature DB >> 15474331

The role of integrins in tumor angiogenesis.

Rosa Hwang1, Judy Varner.   

Abstract

Integrins are cell adhesion molecules that play an important role in the regulation of angiogenesis. In this overview, the vascular integrins and their mechanisms of action are outlined. Integrins have been evaluated in preclinical and clinical studies for the treatment of cancer and as diagnostic markers of angiogenesis. Furthermore, integrins are the basis for targeted therapy for solid tumors and novel imaging techniques to assess the angiogenic response of tumors.

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Year:  2004        PMID： 15474331     DOI： 10.1016/j.hoc.2004.09.010

Source DB:  PubMed          Journal:  Hematol Oncol Clin North Am        ISSN： 0889-8588            Impact factor:   3.722


  29 in total

1.  In vivo imaging of tumour angiogenesis in mice with the alpha(v)beta (3) integrin-targeted tracer 99mTc-RAFT-RGD.

Authors:  Lucie Sancey; Valérie Ardisson; Laurent M Riou; Mitra Ahmadi; Danièle Marti-Batlle; Didier Boturyn; Pascal Dumy; Daniel Fagret; Catherine Ghezzi; Jean-Philippe Vuillez
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-08-04       Impact factor: 9.236

2.  Improving tumor uptake and excretion kinetics of 99mTc-labeled cyclic arginine-glycine-aspartic (RGD) dimers with triglycine linkers.

Authors:  Jiyun Shi; Lijun Wang; Young-Seung Kim; Shizhen Zhai; Zhaofei Liu; Xiaoyuan Chen; Shuang Liu
Journal:  J Med Chem       Date:  2008-12-25       Impact factor: 7.446

3.  Evaluation of the mRNA expression levels of integrins α3, α5, β1 and β6 as tumor biomarkers of oral squamous cell carcinoma.

Authors:  Hsueh-Wei Chang; Ching-Yu Yen; Chung-Ho Chen; Jun-Hsu Tsai; Jen-Yang Tang; Yung-Ting Chang; Yu-Hsun Kao; Yen-Yun Wang; Shyng-Shiou F Yuan; Sheng-Yang Lee
Journal:  Oncol Lett       Date:  2018-07-18       Impact factor: 2.967

4.  F-18 Labeled RGD Probes Based on Bioorthogonal Strain-Promoted Click Reaction for PET Imaging.

Authors:  Hye Lan Kim; Kalme Sachin; Hyeon Jin Jeong; Wonsil Choi; Hyun Soo Lee; Dong Wook Kim
Journal:  ACS Med Chem Lett       Date:  2015-02-06       Impact factor: 4.345

5.  MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides.

Authors:  Orit Jacobson; Lei Zhu; Gang Niu; Ido D Weiss; Lawrence P Szajek; Ying Ma; Xilin Sun; Yongjun Yan; Dale O Kiesewetter; Shuang Liu; Xiaoyuan Chen
Journal:  Mol Imaging Biol       Date:  2011-12       Impact factor: 3.488

6.  Correlation of integrin beta3 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of gastric carcinoma.

Authors:  Shu-Guang Li; Zai-Yuan Ye; Zhong-Sheng Zhao; Hou-Quan Tao; Yuan-Yu Wang; Chun-Yu Niu
Journal:  World J Gastroenterol       Date:  2008-01-21       Impact factor: 5.742

7.  Coligand effects on the solution stability, biodistribution and metabolism of the (99m)Tc-labeled cyclic RGDfK tetramer.

Authors:  Shuang Liu; Young-Seung Kim; Wen-Yuan Hsieh; Subramanya Gupta Sreerama
Journal:  Nucl Med Biol       Date:  2007-11-19       Impact factor: 2.408

Review 8.  Radiolabeled cyclic RGD peptides as integrin alpha(v)beta(3)-targeted radiotracers: maximizing binding affinity via bivalency.

Authors:  Shuang Liu
Journal:  Bioconjug Chem       Date:  2009-12       Impact factor: 4.774

9.  (99m)Tc-Galacto-RGD2: a novel 99mTc-labeled cyclic RGD peptide dimer useful for tumor imaging.

Authors:  Shundong Ji; Andrzej Czerwinski; Yang Zhou; Guoqiang Shao; Francisco Valenzuela; Paweł Sowiński; Satendra Chauhan; Michael Pennington; Shuang Liu
Journal:  Mol Pharm       Date:  2013-08-06       Impact factor: 4.939

10.  Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers.

Authors:  Jiyun Shi; Young-Seung Kim; Shizhen Zhai; Zhaofei Liu; Xiaoyuan Chen; Shuang Liu
Journal:  Bioconjug Chem       Date:  2009-04       Impact factor: 4.774
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