OBJECTIVE: To determine whether an association exists between the histopathologic diagnosis of adenomyosis and infertility in a population of captive baboons. DESIGN: Case-control study. SETTING: Southwest National Primate Research Center. ANIMAL(S): Necropsy records of 37 baboons diagnosed with adenomyosis uteri and 38 baboons with normal uterine histology. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Chi2 analysis of the association between adenomyosis, primary infertility, and the presence of coexisting endometriosis. RESULT(S): Endometriosis was associated with the presence of adenomyosis (OR = 31.5, 95% CI 4.2-1,348). There was a trend toward an association of endometriosis with the presence of lifelong infertility, but this correlation did not quite achieve statistical significance (OR = 3.6, 95% CI 0.9-15.8). Adenomyosis was associated with the presence of lifelong infertility (OR = 20.6, 95% CI 2.7-897). This association was maintained when cases of coexisting endometriosis (n = 17) were excluded (OR = 20.1, 95% CI 2.1-921). CONCLUSION(S): Adenomyosis is strongly associated with lifelong primary infertility in the baboon, even in the absence of coexisting endometriosis.
OBJECTIVE: To determine whether an association exists between the histopathologic diagnosis of adenomyosis and infertility in a population of captive baboons. DESIGN: Case-control study. SETTING: Southwest National Primate Research Center. ANIMAL(S): Necropsy records of 37 baboons diagnosed with adenomyosis uteri and 38 baboons with normal uterine histology. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Chi2 analysis of the association between adenomyosis, primary infertility, and the presence of coexisting endometriosis. RESULT(S): Endometriosis was associated with the presence of adenomyosis (OR = 31.5, 95% CI 4.2-1,348). There was a trend toward an association of endometriosis with the presence of lifelong infertility, but this correlation did not quite achieve statistical significance (OR = 3.6, 95% CI 0.9-15.8). Adenomyosis was associated with the presence of lifelong infertility (OR = 20.6, 95% CI 2.7-897). This association was maintained when cases of coexisting endometriosis (n = 17) were excluded (OR = 20.1, 95% CI 2.1-921). CONCLUSION(S): Adenomyosis is strongly associated with lifelong primary infertility in the baboon, even in the absence of coexisting endometriosis.
Authors: Yugendar R Bommineni; Edward J Dick; Adinarayana R Malapati; Michael A Owston; Gene B Hubbard Journal: J Med Primatol Date: 2011-01-13 Impact factor: 0.667
Authors: Edward J Dick; Michael A Owston; John M David; R Mark Sharp; Scott Rouse; Gene B Hubbard Journal: J Med Primatol Date: 2014-02-01 Impact factor: 0.667