Literature DB >> 15474045

The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.

Mike Boxem1, Chiawei W Tsai, Yi Zhang, R Mako Saito, Jun O Liu.   

Abstract

We have investigated the physiological function of type 2 methionine aminopeptidases (MetAP2) using Caenorhabditis elegans as a model system. A homolog of human MetAP2 was found in the C. elegans genome, which we termed MAP-2. MAP-2 protein displayed methionine aminopeptidase activity and was sensitive to inhibition by fumagillin. Downregulation of map-2 expression by RNAi led to sterility, resulting from a defect in germ cell proliferation. These observations suggest that MAP-2 is essential for germ cell development in C. elegans and that this ubiquitous enzyme may play important roles in a tissue specific manner. Copyright 2004 Federation of European Biochemical Societies

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Year:  2004        PMID： 15474045     DOI： 10.1016/j.febslet.2004.08.077

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

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4.  Cotranslational proteolysis dominates glutathione homeostasis to support proper growth and development.

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Authors:  Nitesh V Sule; Angel Ugrinov; Sanku Mallik; D K Srivastava
Journal:  Biochim Biophys Acta       Date:  2014-10-24

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Journal:  Chem Biol       Date:  2010-01-29

8.  Molecular cloning and characterization of a gene encoding methionine aminopeptidase 2 of Schistosoma japonicum.

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Journal:  Parasitol Res       Date:  2010-06-26       Impact factor: 2.289

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Authors:  Xiaochun Chen; Curtis R Chong; Lirong Shi; Tadashi Yoshimoto; David J Sullivan; Jun O Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-18       Impact factor: 11.205

10.  Functional and developmental impact of cytosolic protein N-terminal methionine excision in Arabidopsis.

Authors:  Simon Ross; Carmela Giglione; Michèle Pierre; Christelle Espagne; Thierry Meinnel
Journal:  Plant Physiol       Date:  2005-01-28       Impact factor: 8.340
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