Literature DB >> 15472801

Voriconazole-induced QT interval prolongation and ventricular tachycardia: a non-concentration-dependent adverse effect.

Y Alkan1, W E Haefeli, J Burhenne, J Stein, I Yaniv, I Shalit.   

Abstract

A 15-year-old patient with acute lymphoblastic leukemia and Fusarium infection was treated with voriconazole. She developed asymptomatic bradycardia, QT interval prolongation, and nonsustained, polymorphic ventricular tachycardia, which recurred upon rechallenge with the drug. Voriconazole levels and metabolism were within expected normal values. This non-concentration-dependent, voriconazole-associated ventricular tachycardia mandates cardiac rhythm monitoring during voriconazole treatment.

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Year:  2004        PMID： 15472801     DOI： 10.1086/423275

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  13 in total

1.  Voriconazole-induced bradycardia without QT interval prolongation: a possible non-concentration-dependent adverse effect.

Authors:  Sébastien Perbet; Raiko Blondonnet; Renaud Guérin; Sophie Cayot-Constantin; Jean-Michel Constantin
Journal:  Intensive Care Med       Date:  2013-01-05       Impact factor: 17.440

2.  Cardiac QTc interval characteristics before and after hematopoietic stem cell transplantation: an analysis of 995 consecutive patients at a single center.

Authors:  W P Miller; R Shanley; P Dorostkar
Journal:  Bone Marrow Transplant       Date:  2015-03-30       Impact factor: 5.483

3.  Voriconazole-induced QT prolongation among hemato-oncologic patients: clinical characteristics and risk factors.

Authors:  I Gueta; R Loebstein; N Markovits; Y Kamari; H Halkin; G Livni; H Yarden-Bilavsky
Journal:  Eur J Clin Pharmacol       Date:  2017-06-17       Impact factor: 2.953

4.  Torsades de pointes associated with methadone and voriconazole.

Authors:  Jennifer A Reinhold; Cynthia A Sanoski; Andrea M Russo; Joshua M Cooper; Sarah A Spinler
Journal:  BMJ Case Rep       Date:  2009-12-22

5.  Effect of combined fluoroquinolone and azole use on QT prolongation in hematology patients.

Authors:  John D Zeuli; John W Wilson; Lynn L Estes
Journal:  Antimicrob Agents Chemother       Date:  2012-12-10       Impact factor: 5.191

Review 6.  Voriconazole : a review of its use in the management of invasive fungal infections.

Authors:  Lesley J Scott; Dene Simpson
Journal:  Drugs       Date:  2007       Impact factor: 9.546

7.  Drug-Drug Interaction Associated with Mold-Active Triazoles among Hospitalized Patients.

Authors:  David Andes; Nkechi Azie; Hongbo Yang; Rachel Harrington; Caroline Kelley; Ruo-Ding Tan; Eric Q Wu; Billy Franks; Rita Kristy; Edward Lee; Nikhil Khandelwal; James Spalding
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191

8.  Voriconazole associated torsades de pointes in two adult patients with haematological malignancies.

Authors:  Jeremy D Brown; Lyn-Li Lim; Sonia Koning
Journal:  Med Mycol Case Rep       Date:  2014-03-13

9.  Update on the treatment of disseminated fusariosis: Focus on voriconazole.

Authors:  Marta Stanzani; Fabio Tumietto; Nicola Vianelli; Michele Baccarani
Journal:  Ther Clin Risk Manag       Date:  2007-12       Impact factor: 2.423

10.  Long QT Syndrome Leading to Multiple Cardiac Arrests After Posaconazole Administration in an Immune-Compromised Patient with Sepsis: An Unusual Case Report.

Authors:  George Panos; Dimitrios Velissaris; Vasilios Karamouzos; Charalampos Matzaroglou; Minos Tylianakis
Journal:  Am J Case Rep       Date:  2016-04-29
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