Literature DB >> 15469020

[A new synthesis of alpha-methylspermidine].

N A Grigorenko, J Vepsalainen, A Jarvinen, T A Keinanen, L Alhonen, J Janne, A M Kritsyn, A R Khomutov.   

Abstract

A five-step synthesis of alpha-methylspermidine (1,8-diamino-5-azanonane), the first polyamine analogue preventing pathological consequences of spermidine depletion in transgenic rats overproducing spermine/spermidine N'-acetyltransferase, from ethyl 3-aminobutyrate was achieved in a high overall yield.

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Year:  2004        PMID： 15469020     DOI： 10.1023/b:rubi.0000037268.98349.ce

Source DB:  PubMed          Journal:  Bioorg Khim        ISSN： 0132-3423


  2 in total

1.  Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.

Authors:  Mervi T Hyvönen; Tuomo A Keinänen; Maxim Khomutov; Alina Simonian; Jouko Vepsäläinen; Jong Hwan Park; Alex R Khomutov; Leena Alhonen; Myung Hee Park
Journal:  Amino Acids       Date:  2011-08-23       Impact factor: 3.520

2.  activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality.

Authors:  Mervi T Hyvönen; Karl-Heinz Herzig; Riitta Sinervirta; Elke Albrecht; Isto Nordback; Juhani Sand; Tuomo A Keinänen; Jouko Vepsäläinen; Nikolay Grigorenko; Alex R Khomutov; Burkhard Krüger; Juhani Jänne; Leena Alhonen
Journal:  Am J Pathol       Date:  2006-01       Impact factor: 4.307
  2 in total

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