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Literature DB >> 15468140

Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla.

Lana G Kaiser¹, Norbert Schuff, Nathan Cashdollar, Michael W Weiner.

Abstract

The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test-retest studies performed on 10 normal subjects demonstrated coefficient of variation for scyllo-inositol measurement of 37%, compared with 6% for N-acetyl aspartate. Comparisons between old and young subjects showed higher concentration of scyllo-inositol and myo-inositol in older subjects and a trend for a correlation between scyllo-inositol and myo-inositol levels across subjects. Copyright 2004 John Wiley & Sons, Ltd.

Entities: Chemical Species

Mesh：

Substances：
Protons
scyllitol
Inositol

Year: 2005 PMID： 15468140 PMCID： PMC1820854 DOI： 10.1002/nbm.927

Source DB: PubMed Journal: NMR Biomed ISSN： 0952-3480 Impact factor: 4.044

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