INTRODUCTION: The temporal course of recovery of depressed patients' cognitive impairment is not fully understood. METHODS: We used the California Verbal Learning Test (CVLT) to test declarative memory in 24 depressed patients before and after 35 days of antidepressive treatment as well as after long-term follow-up (> 12 months) in order to relate improvement of depression to recovery of cognitive impairment. RESULTS: Patients with complete remission after 35 days had generally been less impaired at baseline. The disturbance of declarative memory in treatment responders as well as in non-responders did not change from baseline to end of treatment (day 35). However, our results revealed normal values in the CVLT sum score as well as in measures of short- and long-delay free-recall measures in both groups after long-term full remission. DISCUSSION: We conclude that clinical response to antidepressive treatment precedes improvement of declarative memory. A low degree of impairment of declarative memory is associated with early complete remission of depression.
RCT Entities:
INTRODUCTION: The temporal course of recovery of depressedpatients' cognitive impairment is not fully understood. METHODS: We used the California Verbal Learning Test (CVLT) to test declarative memory in 24 depressedpatients before and after 35 days of antidepressive treatment as well as after long-term follow-up (> 12 months) in order to relate improvement of depression to recovery of cognitive impairment. RESULTS:Patients with complete remission after 35 days had generally been less impaired at baseline. The disturbance of declarative memory in treatment responders as well as in non-responders did not change from baseline to end of treatment (day 35). However, our results revealed normal values in the CVLT sum score as well as in measures of short- and long-delay free-recall measures in both groups after long-term full remission. DISCUSSION: We conclude that clinical response to antidepressive treatment precedes improvement of declarative memory. A low degree of impairment of declarative memory is associated with early complete remission of depression.
Authors: Jan Engelmann; Stefanie Wagner; Daniel Wollschläger; Sabine Kaaden; Konrad F Schlicht; Nadine Dreimüller; Dieter F Braus; Marianne B Müller; Oliver Tüscher; Helge Frieling; André Tadić; Klaus Lieb Journal: Eur Arch Psychiatry Clin Neurosci Date: 2019-03-30 Impact factor: 5.270
Authors: Allison G Harvey; Jason Lee; Rita L Smith; Nicole B Gumport; Steven D Hollon; Sophia Rabe-Hesketh; Kerrie Hein; Michael R Dolsen; Kirsten L Haman; Jennifer C Kanady; Monique A Thompson; Deidre Abrons Journal: Behav Res Ther Date: 2016-04-02
Authors: Lara G Chepenik; Fei Wang; Linda Spencer; Marisa Spann; Jessica H Kalmar; Fay Womer; E Kale Edmiston; Brian Pittman; Hilary P Blumberg Journal: Biol Psychol Date: 2012-02-10 Impact factor: 3.251
Authors: Taylor A James; Samuel Weiss-Cowie; Zachary Hopton; Paul Verhaeghen; Vonetta M Dotson; Audrey Duarte Journal: Psychol Bull Date: 2021-11 Impact factor: 23.027
Authors: Tarique D Perera; Andrew J Dwork; Kathryn A Keegan; Lakshmi Thirumangalakudi; Cecilia M Lipira; Niamh Joyce; Christopher Lange; J Dee Higley; Gorazd Rosoklija; Rene Hen; Harold A Sackeim; Jeremy D Coplan Journal: PLoS One Date: 2011-04-15 Impact factor: 3.240
Authors: Allison G Harvey; Lu Dong; Jason Y Lee; Nicole B Gumport; Steven D Hollon; Sophia Rabe-Hesketh; Kerrie Hein; Kirsten Haman; Mary E McNamara; Claire Weaver; Armando Martinez; Haruka Notsu; Garret Zieve; Courtney C Armstrong Journal: Trials Date: 2017-11-14 Impact factor: 2.279