Literature DB >> 15467824

IRS2 takes center stage in the development of type 2 diabetes.

Matthew J Brady1.   

Abstract

The etiology of type 2 diabetes is characterized by obesity, insulin and leptin resistance, and compensatory beta cell hyperplasia followed by islet degeneration, resulting in the eventual dysregulation of glucose and lipid homeostasis. The recent identification of insulin receptor substrate 2 (IRS2) as a central player in the pathophysiology of many of these processes suggests a potentially unifying molecular link underlying the initiation and progression of type 2 diabetes.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15467824      PMCID： PMC518671          DOI： 10.1172/JCI23108

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  16 in total

Review 1.  Pancreatic stem cells.

Authors:  Susan Bonner-Weir; Arun Sharma
Journal:  J Pathol       Date:  2002-07       Impact factor: 7.996

2.  Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.

Authors:  Yuval Dor; Juliana Brown; Olga I Martinez; Douglas A Melton
Journal:  Nature       Date:  2004-05-06       Impact factor: 49.962

3.  Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

Authors:  E Araki; M A Lipes; M E Patti; J C Brüning; B Haag; R S Johnson; C R Kahn
Journal:  Nature       Date:  1994-11-10       Impact factor: 49.962

Review 4.  IRS proteins and the common path to diabetes.

Authors:  Morris F White
Journal:  Am J Physiol Endocrinol Metab       Date:  2002-09       Impact factor: 4.310

5.  Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

Authors:  H Tamemoto; T Kadowaki; K Tobe; T Yagi; H Sakura; T Hayakawa; Y Terauchi; K Ueki; Y Kaburagi; S Satoh
Journal:  Nature       Date:  1994-11-10       Impact factor: 49.962

6.  Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus.

Authors:  Naoto Kubota; Yasuo Terauchi; Kazuyuki Tobe; Wataru Yano; Ryo Suzuki; Kohjiro Ueki; Iseki Takamoto; Hidemi Satoh; Toshiyuki Maki; Tetsuya Kubota; Masao Moroi; Miki Okada-Iwabu; Osamu Ezaki; Ryozo Nagai; Yoichi Ueta; Takashi Kadowaki; Tetsuo Noda
Journal:  J Clin Invest       Date:  2004-10       Impact factor: 14.808

7.  Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.

Authors:  Xueying Lin; Akiko Taguchi; Sunmin Park; Jake A Kushner; Fan Li; Yedan Li; Morris F White
Journal:  J Clin Invest       Date:  2004-10       Impact factor: 14.808

Review 8.  Insulin and leptin as adiposity signals.

Authors:  Stephen C Benoit; Deborah J Clegg; Randy J Seeley; Stephen C Woods
Journal:  Recent Prog Horm Res       Date:  2004

Review 9.  Mouse models of insulin resistance.

Authors:  Anindita Nandi; Yukari Kitamura; C Ronald Kahn; Domenico Accili
Journal:  Physiol Rev       Date:  2004-04       Impact factor: 37.312

Review 10.  Leptin signaling in the central nervous system and the periphery.

Authors:  Christian Bjørbaek; Barbara B Kahn
Journal:  Recent Prog Horm Res       Date:  2004
View more
  17 in total

1.  Disruption of glucose homeostasis and induction of insulin resistance by elevated free fatty acids in human L02 hepatocytes.

Authors:  X-D Wan; W-B Yang; Y-Z Xia; J-F Wang; T Lu; X-M Wang
Journal:  J Endocrinol Invest       Date:  2009-04-29       Impact factor: 4.256

2.  Changes in glucose metabolism and mRNA expression of IRS-2 in rats exposed to phoxim and the protective effects of vitamin E.

Authors:  Jing Zhang; Wentao Song; Yuecheng Sun; Baojing Cheng; Anshan Shan
Journal:  Toxicol Res (Camb)       Date:  2017-12-01       Impact factor: 3.524

3.  Resequencing of IRS2 reveals rare variants for obesity but not fasting glucose homeostasis in Hispanic children.

Authors:  Nancy F Butte; V Saroja Voruganti; Shelley A Cole; Karin Haack; Anthony G Comuzzie; Donna M Muzny; David A Wheeler; Kyle Chang; Alicia Hawes; Richard A Gibbs
Journal:  Physiol Genomics       Date:  2011-07-19       Impact factor: 3.107

4.  The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

Authors:  Agharul I Choudhury; Helen Heffron; Mark A Smith; Hind Al-Qassab; Allison W Xu; Colin Selman; Marcus Simmgen; Melanie Clements; Marc Claret; Gavin Maccoll; David C Bedford; Kazunari Hisadome; Ivan Diakonov; Vazira Moosajee; Jimmy D Bell; John R Speakman; Rachel L Batterham; Gregory S Barsh; Michael L J Ashford; Dominic J Withers
Journal:  J Clin Invest       Date:  2005-03-24       Impact factor: 14.808

5.  Cord Blood from SGA Preterm Infants Exhibits Increased GLUT4 mRNA Expression.

Authors:  Satoshi Narai; Yuki Kawashima-Sonoyama; Masanobu Fujimoto; Mazumi Miura; Kaori Adachi; Eiji Nanba; Noriyuki Namba
Journal:  Yonago Acta Med       Date:  2021-01-20       Impact factor: 1.641

6.  Single nucleotide polymorphisms in binding site of miRNA-135a and targeted gene IRS2 are correlated with multiple clinical features of PCOS: A study in Chinese women.

Authors:  Heng Gu; Longyu Li; Bingyi Zhou; Mingzhen Li; Wenyao Zhong; Xiangcai Wei; Xingmin Zhong
Journal:  Technol Health Care       Date:  2022       Impact factor: 1.205

7.  Edible Bird's Nest Prevents High Fat Diet-Induced Insulin Resistance in Rats.

Authors:  Zhang Yida; Mustapha Umar Imam; Maznah Ismail; Der-Jiun Ooi; Nadarajan Sarega; Nur Hanisah Azmi; Norsharina Ismail; Kim Wei Chan; Zhiping Hou; Norhayati Binti Yusuf
Journal:  J Diabetes Res       Date:  2015-07-27       Impact factor: 4.011

8.  Nutrigenomic effects of edible bird's nest on insulin signaling in ovariectomized rats.

Authors:  Zhiping Hou; Mustapha Umar Imam; Maznah Ismail; Der Jiun Ooi; Aini Ideris; Rozi Mahmud
Journal:  Drug Des Devel Ther       Date:  2015-08-14       Impact factor: 4.162

9.  N-Acetylneuraminic Acid Supplementation Prevents High Fat Diet-Induced Insulin Resistance in Rats through Transcriptional and Nontranscriptional Mechanisms.

Authors:  Zhang Yida; Mustapha Umar Imam; Maznah Ismail; Norsharina Ismail; Nur Hanisah Azmi; Waiteng Wong; Hadiza Altine Adamu; Nur Diyana Md Zamri; Aini Ideris; Maizaton Atmadini Abdullah
Journal:  Biomed Res Int       Date:  2015-11-25       Impact factor: 3.411

10.  Changes in selective pressures associated with human population expansion may explain metabolic and immune related pathways enriched for signatures of positive selection.

Authors:  Alexandra I Vatsiou; Eric Bazin; Oscar E Gaggiotti
Journal:  BMC Genomics       Date:  2016-07-21       Impact factor: 3.969
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.