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Literature DB >> 15467822

Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus.

Abstract

Islet transplantation represents a most impressive recent advance in the search for a type 1 diabetes mellitus cure. While several hundred patients have achieved at least temporary insulin independence after receiving the islet "mini-organs" (containing insulin-producing beta cells), very few patients remain insulin independent beyond 4 years after transplantation. In this review, we describe historic as well as technical details about the procedure and provide insight into clinical and basic research efforts to overcome existing hurdles for this promising therapy.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15467822 PMCID： PMC518676 DOI： 10.1172/JCI23235

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

85 in total

1. Histopathological study of intrahepatic islets transplanted in the nonhuman primate model using edmonton protocol immunosuppression.

Authors: Boaz Hirshberg; Steven Mog; Noelle Patterson; John Leconte; David M Harlan
Journal: J Clin Endocrinol Metab Date: 2002-12 Impact factor: 5.958

2. Portal venous pressure changes after sequential clinical islet transplantation.

Authors: John J Casey; Jonathan R Lakey; Edmond A Ryan; Breay W Paty; Richard Owen; Kevin O'Kelly; Sulaiman Nanji; Ray V Rajotte; Gregory S Korbutt; David Bigam; Norman N Kneteman; A M Shapiro
Journal: Transplantation Date: 2002-10-15 Impact factor: 4.939

3. Unraveling the secrets of single donor success in islet transplantation.

Authors: A M James Shapiro; Camillo Ricordi
Journal: Am J Transplant Date: 2004-03 Impact factor: 8.086

4. A novel approach to increase human islet cell mass while preserving beta-cell function.

Authors: Gillian M Beattie; Anthony M P Montgomery; Ana D Lopez; Ergeng Hao; Brandon Perez; Margaret L Just; Jonathan R T Lakey; Marquis E Hart; Alberto Hayek
Journal: Diabetes Date: 2002-12 Impact factor: 9.461

5. Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation.

Authors: Juan Carlos Lopez-Talavera; Adolfo Garcia-Ocaña; Ian Sipula; Karen K Takane; Irene Cozar-Castellano; Andrew F Stewart
Journal: Endocrinology Date: 2003-10-09 Impact factor: 4.736

6. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells.

Authors: Yuichi Hori; Ingrid C Rulifson; Bernette C Tsai; Jeremy J Heit; John D Cahoy; Seung K Kim
Journal: Proc Natl Acad Sci U S A Date: 2002-11-19 Impact factor: 11.205

7. Risk factors for coronary heart disease in type 1 diabetic patients in Europe: the EURODIAB Prospective Complications Study.

Authors: Sabita S Soedamah-Muthu; Nish Chaturvedi; Monika Toeller; Barry Ferriss; Paolo Reboldi; Georges Michel; Christos Manes; John H Fuller
Journal: Diabetes Care Date: 2004-02 Impact factor: 19.112

8. Insulin secretion in type 1 diabetes.

Authors: Chynna Steele; William A Hagopian; Stephen Gitelman; Umesh Masharani; Melissa Cavaghan; Kristina I Rother; David Donaldson; David M Harlan; Jeffrey Bluestone; Kevan C Herold
Journal: Diabetes Date: 2004-02 Impact factor: 9.461

9. Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes.

Authors: Behrous Davani; Neil Portwood; Galina Bryzgalova; Martina Kvist Reimer; Thomas Heiden; Claes-Göran Ostenson; Sam Okret; Bo Ahren; Suad Efendic; Akhtar Khan
Journal: Diabetes Date: 2004-02 Impact factor: 9.461

10. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation.

Authors: L Moberg; H Johansson; A Lukinius; C Berne; A Foss; R Källen; Ø Østraat; K Salmela; A Tibell; G Tufveson; G Elgue; K Nilsson Ekdahl; O Korsgren; B Nilsson
Journal: Lancet Date: 2002 Dec 21-28 Impact factor: 79.321

66 in total

Review 1. Islet transplantation: current status and future directions.

Authors: Betul Hatipoglu; Enrico Benedetti; José Oberholzer
Journal: Curr Diab Rep Date: 2005-08 Impact factor: 4.810

Review 2. Assessment of islet function following islet and pancreas transplantation.

Authors: Emily C Dy; David M Harlan; Kristina I Rother
Journal: Curr Diab Rep Date: 2006-08 Impact factor: 4.810

Review 3. Facilitating physiologic self-regeneration: a step beyond islet cell replacement.

Authors: Pleunie P M Rood; Rita Bottino; A N Balamurugan; Yong Fan; David K C Cooper; Massimo Trucco
Journal: Pharm Res Date: 2006-01-01 Impact factor: 4.200

Review 4. Cellular therapies for type 1 diabetes.

Authors: D D Lee; E Grossman; A S Chong
Journal: Horm Metab Res Date: 2008-02 Impact factor: 2.936

5. Current status of clinical islet transplantation.

Authors: Andrew R Pepper; Boris Gala-Lopez; Oliver Ziff; Am James Shapiro
Journal: World J Transplant Date: 2013-12-24

6. Fibrin supports human fetal islet-epithelial cell differentiation via p70(s6k) and promotes vascular formation during transplantation.

Authors: Matthew Riopel; Jinming Li; Mark Trinder; George F Fellows; Rennian Wang
Journal: Lab Invest Date: 2015-06-01 Impact factor: 5.662

7. Deficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model.

Authors: E J Zmuda; M Viapiano; S T Grey; G Hadley; A Garcia-Ocaña; T Hai
Journal: Diabetologia Date: 2010-03-28 Impact factor: 10.122