BACKGROUND: Although Clara cell secretory protein (CC-10) has been ascribed an anti-inflammatory role in lung diseases, its precise role remains unclear. OBJECTIVE: To further our understanding of the role of CC-10 in inflammatory lung diseases, CC-10 protein levels were measured. METHODS: Sera or bronchoalveolar lavage (BAL) fluids were collected from patients with different inflammatory lung diseases including bronchial asthma, chronic obstructive lung disease (COPD), sarcoidosis, idiopathic interstitial pneumonia (IIP), chronic eosinophilic pneumonia (CEP), pneumonia and lung cancer. Serum CC-10 concentrations were measured by enzyme-linked immunosorbent assay using urinary protein-1 antibody. Then, the relationships between CC-10 concentrations and lung diseases were investigated. Immunohistochemistry was performed using lung biopsy samples. RESULTS: Increased serum CC-10 levels were recognized in IIP patients, while CC-10 levels were decreased in bronchial asthma patients and CEP patients. Immunohistochemistry revealed an aberrant expression in areas of fibrosis in IIP patients. Serum CC-10 concentrations were not associated with severity among IIP, COPD, and sarcoidosis. In contrast, serum CC-10 concentrations were correlated with FEV(1)/FVC in bronchial asthma patients. CONCLUSIONS: Although the number of patients was quite limited, these data provide new insights into the role of CC-10 in lung diseases, and the possibility that the CC-10 concentration in serum could be a new marker indicating the severity of bronchial asthma.
BACKGROUND: Although Clara cell secretory protein (CC-10) has been ascribed an anti-inflammatory role in lung diseases, its precise role remains unclear. OBJECTIVE: To further our understanding of the role of CC-10 in inflammatory lung diseases, CC-10 protein levels were measured. METHODS: Sera or bronchoalveolar lavage (BAL) fluids were collected from patients with different inflammatory lung diseases including bronchial asthma, chronic obstructive lung disease (COPD), sarcoidosis, idiopathic interstitial pneumonia (IIP), chronic eosinophilic pneumonia (CEP), pneumonia and lung cancer. Serum CC-10 concentrations were measured by enzyme-linked immunosorbent assay using urinary protein-1 antibody. Then, the relationships between CC-10 concentrations and lung diseases were investigated. Immunohistochemistry was performed using lung biopsy samples. RESULTS: Increased serum CC-10 levels were recognized in IIP patients, while CC-10 levels were decreased in bronchial asthmapatients and CEPpatients. Immunohistochemistry revealed an aberrant expression in areas of fibrosis in IIP patients. Serum CC-10 concentrations were not associated with severity among IIP, COPD, and sarcoidosis. In contrast, serum CC-10 concentrations were correlated with FEV(1)/FVC in bronchial asthmapatients. CONCLUSIONS: Although the number of patients was quite limited, these data provide new insights into the role of CC-10 in lung diseases, and the possibility that the CC-10 concentration in serum could be a new marker indicating the severity of bronchial asthma.
Authors: Stefano Guerra; Marilyn Halonen; Monica M Vasquez; Amber Spangenberg; Debra A Stern; Wayne J Morgan; Anne L Wright; Iris Lavi; Lluïsa Tarès; Anne-Elie Carsin; Carlota Dobaño; Esther Barreiro; Jan-Paul Zock; Jesús Martínez-Moratalla; Isabel Urrutia; Jordi Sunyer; Dirk Keidel; Medea Imboden; Nicole Probst-Hensch; Jenny Hallberg; Erik Melén; Magnus Wickman; Jean Bousquet; Danielle C M Belgrave; Angela Simpson; Adnan Custovic; Josep M Antó; Fernando D Martinez Journal: Lancet Respir Med Date: 2015-07-06 Impact factor: 30.700
Authors: Christian Rosas-Salazar; Tebeb Gebretsadik; Kecia N Carroll; Sara Reiss; Nancy Wickersham; Emma K Larkin; Kristina M James; E Kathryn Miller; Larry J Anderson; Tina V Hartert Journal: Pediatr Allergy Immunol Pulmonol Date: 2015-09-01 Impact factor: 1.349
Authors: Erik Melén; Alvin T Kho; Sunita Sharma; Roger Gaedigk; J Steven Leeder; Thomas J Mariani; Vincent J Carey; Scott T Weiss; Kelan G Tantisira Journal: Respir Res Date: 2011-06-23
Authors: Marijke J Vanspauwen; Catharina F M Linssen; Cathrien A Bruggeman; Jan A Jacobs; Marjolein Drent; Dennis C J J Bergmans; Walther N K A van Mook Journal: Crit Care Date: 2011-01-11 Impact factor: 9.097