OBJECTIVE: The authors hypothesized that changes in brain membrane composition resulting from omega-3 fatty acid administration in patients with bipolar disorder would result in greater membrane fluidity, as detected by reductions in T(2) values. METHOD:Women with bipolar disorder (N=12) receivedomega-3 fatty acids for 4 weeks. A cohort of bipolar subjects (N=9) and a group without bipolar disorder (N=12) did not receiveomega-3 fatty acids. T(2) values were acquired at baseline and after 4 weeks. RESULTS: Bipolar subjects who received omega-3 fatty acids had significant decreases in T(2). There was a dose-dependent effect when the bipolar omega-3 fatty acid group was subdivided into high- and low-dose cohorts. CONCLUSIONS:Omega-3fatty acids lowered T(2) values, consistent with the hypothesis that the fluidity of cell membranes was altered. Further studies are needed to clarify the significance of alterations in brain physiology induced by omega-3 fatty acids, as reflected in T(2) values.
RCT Entities:
OBJECTIVE: The authors hypothesized that changes in brain membrane composition resulting from omega-3 fatty acid administration in patients with bipolar disorder would result in greater membrane fluidity, as detected by reductions in T(2) values. METHOD:Women with bipolar disorder (N=12) received omega-3 fatty acids for 4 weeks. A cohort of bipolar subjects (N=9) and a group without bipolar disorder (N=12) did not receive omega-3 fatty acids. T(2) values were acquired at baseline and after 4 weeks. RESULTS: Bipolar subjects who received omega-3 fatty acids had significant decreases in T(2). There was a dose-dependent effect when the bipolar omega-3 fatty acid group was subdivided into high- and low-dose cohorts. CONCLUSIONS:Omega-3 fatty acids lowered T(2) values, consistent with the hypothesis that the fluidity of cell membranes was altered. Further studies are needed to clarify the significance of alterations in brain physiology induced by omega-3 fatty acids, as reflected in T(2) values.
Authors: Atilla Gönenç; Jean A Frazier; David J Crowley; Constance M Moore Journal: J Am Acad Child Adolesc Psychiatry Date: 2010-10-29 Impact factor: 8.829
Authors: Ana A Liso Navarro; Elif M Sikoglu; Cailin R Heinze; Ryan C Rogan; Vivienne A Russell; Jean A King; Constance M Moore Journal: Behav Brain Res Date: 2014-05-19 Impact factor: 3.332
Authors: Gabriela D Colpo; Marion Leboyer; Robert Dantzer; Mahdukar H Trivedi; Antonio L Teixeira Journal: Expert Rev Neurother Date: 2017-11-27 Impact factor: 4.618
Authors: Matthew F Muldoon; Christopher M Ryan; Lei Sheu; Jeffrey K Yao; Sarah M Conklin; Stephen B Manuck Journal: J Nutr Date: 2010-02-24 Impact factor: 4.798
Authors: M Elizabeth Sublette; Francesca Bosetti; James C DeMar; Kaizong Ma; Jane M Bell; Stephanie Fagin-Jones; Mark J Russ; Stanley I Rapoport Journal: Bipolar Disord Date: 2007-11 Impact factor: 6.744
Authors: Brian P Brennan; James I Hudson; J Eric Jensen; Julie McCarthy; Jacqueline L Roberts; Andrew P Prescot; Bruce M Cohen; Harrison G Pope; Perry F Renshaw; Dost Ongür Journal: Neuropsychopharmacology Date: 2009-12-02 Impact factor: 7.853
Authors: Anthony T Vesco; Jennifer Lehmann; Barbara L Gracious; L Eugene Arnold; Andrea S Young; Mary A Fristad Journal: J Child Adolesc Psychopharmacol Date: 2015-08-19 Impact factor: 2.576