Literature DB >> 15465598

The chemokine CXCL10 modulates excitatory activity and intracellular calcium signaling in cultured hippocampal neurons.

Thomas E Nelson1, Donna L Gruol.   

Abstract

In this study, we provide evidence for direct modulatory effects of the chemokine, CXCL10, on the physiology of hippocampal neurons maintained in primary culture. CXCL10 elicited a rise in intracellular Ca2+ and enhanced both spontaneous and evoked electrical activity of hippocampal neurons. CXCL10-induced elevations in intracellular Ca2+ were associated with an increase in neuronal firing and an alteration in the relationship between the evoked Ca2+ signal and neuronal activity. The effects of CXCL10 were not accompanied by a shift in resting membrane potential (RMP) or input resistance. Expression of the CXCR3 chemokine receptor supports a direct effect of CXCL10 on hippocampal neurons.

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Year:  2004        PMID： 15465598     DOI： 10.1016/j.jneuroim.2004.07.009

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  32 in total

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4.  Chronic CXCL10 alters the level of activated ERK1/2 and transcriptional factors CREB and NF-kappaB in hippocampal neuronal cell culture.

Authors:  Hilda Bajova; Thomas E Nelson; Donna L Gruol
Journal:  J Neuroimmunol       Date:  2008-03-10       Impact factor: 3.478

5.  The chemokine CCL2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal cells.

Authors:  Jungsook Cho; Donna L Gruol
Journal:  J Neuroimmunol       Date:  2008-06-27       Impact factor: 3.478

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7.  Chronic exposure to the chemokine CCL3 enhances neuronal network activity in rat hippocampal cultures.

Authors:  M Kuijpers; K L I van Gassen; P N E de Graan; D Gruol
Journal:  J Neuroimmunol       Date:  2010-08-01       Impact factor: 3.478

8.  CRH-R1 and CRH-R2 differentially modulate dendritic outgrowth of hippocampal neurons.

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9.  In-depth characterization of the neuroinflammatory reaction induced by peripheral surgery in an animal model.

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10.  Peripherally restricted acute phase response to a viral mimic alters hippocampal gene expression.

Authors:  Lindsay T Michalovicz; Gregory W Konat
Journal:  Metab Brain Dis       Date:  2013-12-24       Impact factor: 3.584
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