| Literature DB >> 15465106 |
Andrey P Antonchick1, Bernd Schneider, Vladimir N Zhabinskii, Vladimir A Khripach.
Abstract
A number of hexadeuterated brassinosteroids (BS) containing a hydroxy group at C-22 or a 22R,23R-diol function were prepared starting from 23,24-bisnorcholenic acid methyl ester for biosynthetic studies. Synthesis of the cyclic part was accomplished via the initial hydroboration-oxidation of Delta(5)-double bond. The key step in the synthesis of the side chain involved addition of (2S)-[3,4-(2)H(6)]2,3-dimethylbutylphenyl sulfone to the corresponding C-22 aldehydes.Entities:
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Year: 2004 PMID： 15465106 DOI： 10.1016/j.steroids.2004.05.014
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668