David C Mohr1, Claude Genain. 1. Departments of Psychiatry and Neurology, and VA Medical Center, University of California-San Francisco, 4150 Clement Street (116-A), San Francisco, CA 94121, USA. dmohr@itsa.ucsf.edu
Abstract
OBJECTIVE: This study examined the buffering effects of social support on the relationship between depression and autoaggressive immune function in multiple sclerosis (MS). METHODS:Fourteen participants with comorbid diagnoses of MS and major depressive disorder received 16 weeks ofpsychotherapy or antidepressant medications. Depression and T-cell production of interferon-gamma (IFN-gamma), a lynchpin in MS pathogenesis, were assessed at baseline and posttreatment. Social support was assessed at baseline. RESULTS:Both depression and T-cell production of IFN-gamma were significantly reduced over the 16 weeks of treatment. There was a significant interaction between change in depression, change in IFN-gamma, and social support (R(2)=.26, P=.03) such that social support served as a buffer. CONCLUSION: These results support the hypothesis that social support buffers the effects of change in depression on IFN-gamma production. However, these findings should be viewed as preliminary due to the small sample size and the absence of a control condition.
RCT Entities:
OBJECTIVE: This study examined the buffering effects of social support on the relationship between depression and autoaggressive immune function in multiple sclerosis (MS). METHODS: Fourteen participants with comorbid diagnoses of MS and major depressive disorder received 16 weeks of psychotherapy or antidepressant medications. Depression and T-cell production of interferon-gamma (IFN-gamma), a lynchpin in MS pathogenesis, were assessed at baseline and posttreatment. Social support was assessed at baseline. RESULTS: Both depression and T-cell production of IFN-gamma were significantly reduced over the 16 weeks of treatment. There was a significant interaction between change in depression, change in IFN-gamma, and social support (R(2)=.26, P=.03) such that social support served as a buffer. CONCLUSION: These results support the hypothesis that social support buffers the effects of change in depression on IFN-gamma production. However, these findings should be viewed as preliminary due to the small sample size and the absence of a control condition.
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