| Literature DB >> 15464837 |
Nareerat Viseshakul1, Roongroje Thanawongnuwech, Alongkorn Amonsin, Sanipa Suradhat, Sunchai Payungporn, Juthatip Keawchareon, Kanisak Oraveerakul, Piya Wongyanin, Sukanya Plitkul, Apiradee Theamboonlers, Yong Poovorawan.
Abstract
In this report, the genome of the Thai avian influenza virus A (H5N1); A/Chicken/Nakorn-Pathom/Thailand/CU-K2/04, isolated from the Thai avian influenza A (AI) epidemic during the early of 2004 was sequenced. Phylogenetic analyses were performed in comparison to AI viruses from Hong Kong 1997 outbreaks and other AI (H5N1) isolates reported during 2001-2004. Molecular characterization of the Thai AI (H5N1) HA gene revealed a common characteristic of a highly pathogenic AI (HPAI), a 20-codon deletion in the neuraminidase gene, a 5-codon deletion in the NS gene and polymorphisms of the M2 and PB2 genes. Moreover, the HA and NA genes of the Thai AI displayed high similarity to those of the AI viruses isolated from human cases during the same epidemic. Finally, our results demonstrated that the Thai AI emerged as a member of 2000's AI lineage with most of the genetic sequences closely related to the Influenza A/Duck/China/E319.2/03 (H5N1).Entities:
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Year: 2004 PMID： 15464837 DOI： 10.1016/j.virol.2004.06.045
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616