Literature DB >> 15464764

Age-related susceptibility to oxygen and glucose deprivation damage in rat hippocampal slices.

Ionara Rodrigues Siqueira1, Helena Cimarosti, Cíntia Fochesatto, Christianne Salbego, Carlos Alexandre Netto.   

Abstract

Aging is an important risk factor for stroke. We evaluated the effects of aging on cell susceptibility to oxygen and glucose deprivation (OGD) in slices of the hippocampus from Wistar rats aged 2, 11 and 24 months. Lactate dehydrogenase (LDH) released to the incubation media and free radical content were markedly increased in the 24-month group submitted to OGD. These results confirm that hippocampal tissue from old animals is more susceptible to ischemia-reoxygenation injury.

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Year:  2004        PMID： 15464764     DOI： 10.1016/j.brainres.2004.08.005

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  16 in total

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