| Literature DB >> 15464747 |
Jaak Panksepp1, Jeff Burgdorf, Margery C Beinfeld, Roger A Kroes, Joseph R Moskal.
Abstract
Cholecystokinin (CCK) is the most abundant neuropeptide in the mammalian brain, and has been implicated in the regulation of a diversity of emotions and motivations including negative affect and stress responses. In this experiment, we assayed levels of CCK (CCK4/5 and CCK8) from tissue homogenates in intruder animals 6 h after resident-intruder inter-male aggression. Intruder animals that demonstrated submissive behavior (freezing and 22-kHz ultrasonic vocalizations) had higher levels of CCK in the tegmentum and posterior cortex as compared to non-submissive (i.e., "Friendly") intruder animals. Ultrasonic vocalizations (22-kHz) were positively correlated with CCK levels in the tegmentum, posterior cortex and pituitary. These data suggest that CCK may play a role in the generation of negative affective states indexed by 22-kHz ultrasonic calls in certain regions of the brain.Entities:
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Year: 2004 PMID： 15464747 DOI： 10.1016/j.brainres.2004.07.076
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252