| Literature DB >> 15464681 |
Giuseppe Mercuro1, Cristiana Vitale, Elena Cerquetani, Sandra Zoncu, Martino Deidda, Massimo Fini, Giuseppe M C Rosano.
Abstract
The aim of the present study was to evaluate the effect of increased serum uric acid (UA) levels and their therapeutic reduction with allopurinol on endothelium-dependent dilation in subjects with a high cardiovascular (CV) risk but who were free from clinical CV disease. Patients with hyperuricemia had impaired flow-mediated dilation (FMD) compared with matched controls with normal UA levels and elevated CV risk. Three-month therapy with allopurinol improved FMD in hyperuricemic subjects, showing an intrinsic negative effect of elevated UA levels on the arterial wall; conversely, FMD remained unchanged in controls, thus suggesting that the reduction of UA to less than a certain value does not affect endothelial function.Entities:
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Year: 2004 PMID： 15464681 DOI： 10.1016/j.amjcard.2004.06.032
Source DB: PubMed Journal: Am J Cardiol ISSN： 0002-9149 Impact factor: 2.778