| Literature DB >> 15464621 |
Boźena Modzelewska-Banachiewicz1, Jacek Banachiewicz, Anna Chodkowska, Ewa Jagiełło-Wójtowicz, Liliana Mazur.
Abstract
New 3-(3,4-diaryl-1,2,4-triazole-5-yl)propenoic acid derivatives (8-14) were synthesized by condensation of N(3)-substituted amidrazones (1-7) with maleic anhydride. Molecular structure of obtained compounds was confirmed by an elemental analysis, IR and (1)H NMR spectra, and the X-ray crystallography for compound 11. The influence of the compound 9 on the central nervous system (CNS) of mice in some behavioural test was examined. The investigated compound showed anticonvulsive activity and potent antinociceptive action.Entities:
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Year: 2004 PMID： 15464621 DOI： 10.1016/j.ejmech.2004.07.002
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514