| Literature DB >> 15464433 |
Keith A Houck1, Kristen M Borchert, Christopher D Hepler, Jeffrey S Thomas, Kelli S Bramlett, Laura F Michael, Thomas P Burris.
Abstract
We characterize the ability of the liver X receptor (LXRalpha [NR1H3] and LXRbeta [NR1H2]) agonist, T0901317, to activate the farnesoid X receptor (FXR [NR4H4]). Although T0901317 is a much more potent activator of LXR than FXR, this ligand actually activates FXR more potently than a natural bile acid FXR ligand, chenodeoxycholic acid. Thus, the FXR activity of T0901317 must be considered when utilizing this agonist as a pharmacological tool to investigate LXR function.Entities:
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Year: 2004 PMID： 15464433 DOI： 10.1016/j.ymgme.2004.07.007
Source DB: PubMed Journal: Mol Genet Metab ISSN： 1096-7192 Impact factor: 4.797