| Literature DB >> 15464397 |
Kiichi Ishiwata1, Masaki Mizuno, Yuichi Kimura, Kazunori Kawamura, Keiichi Oda, Toru Sasaki, Yoshio Nakamura, Isao Muraoka, Kenji Ishii.
Abstract
We examined the potential of [7-methyl-11C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX) for the assessment of adenosine A2A receptors in muscle. In rodents, specific binding of [11C]TMSX was observed in muscle and heart by blockade with A2A-selective CSC and non-selective theophylline, but not with A1-selective DPCPX. Swimming exercise fluctuated radioligand-receptor binding in these tissues. In a PET study of two subjects, theophylline-infusion slightly deceased the distribution volume of [11C]TMSX in the heart (20% reduction) and muscle (10% reduction), which suggested the specific binding.Entities:
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Year: 2004 PMID： 15464397 DOI： 10.1016/j.nucmedbio.2004.06.003
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408