| Literature DB >> 15464083 |
Miguel Navarro1, M Rocio A Carrera, Ignacio Del Arco, Jose Manuel Trigo, George F Koob, Fernando Rodríguez de Fonseca.
Abstract
Functionality of the endogenous cannabinoid system undergoes relevant changes in reward-related brain areas in animal models of opiate addiction. By using a limited access heroin self-administration paradigm we show that cannabinoid CB(1) receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride (SR141716A, 0.03-3.0 mg/kg) suppresses heroin self-administration only in opiate-dependent rats but not in non-dependent animals. These results further support the study of cannabinoid CB(1) receptor antagonists for the treatment of opiate addiction.Entities:
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Year: 2004 PMID： 15464083 DOI： 10.1016/j.ejphar.2004.08.022
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432