Literature DB >> 15464021

Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory intervention.

Heiko Mühl1, Josef Pfeilschifter.   

Abstract

Interleukin-18 is a member of the interleukin-1 family of cytokines with pro-inflammatory and tumor-suppressive properties. Its ability to potently enhance the production of interferon-gamma indicates in particular the crucial function of interleukin-18 as an immunomodulatory molecule. In fact, high levels of interleukin-18 are detected in human diseases associated with immunoactivation including viral or bacterial infections and chronic inflammation. Animal models suggest suppression of interleukin-18 bioactivity as a novel therapeutic concept specifically for the treatment of chronic inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis. Here we introduce into the biology of interleukin-18 and review immunopharmacological strategies that aim at reducing interleukin-18 bioactivity in human disease.

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Year:  2004        PMID： 15464021     DOI： 10.1016/j.ejphar.2004.07.012

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  23 in total

1.  Predictive impact of elevated serum level of IL-18 for early renal dysfunction in type 2 diabetes: an observational follow-up study.

Authors:  S Araki; M Haneda; D Koya; T Sugimoto; K Isshiki; M Chin-Kanasaki; T Uzu; A Kashiwagi
Journal:  Diabetologia       Date:  2007-01-16       Impact factor: 10.122

2.  Aloe vera attenuated gastric injury on indomethacin-induced gastropathy in rats.

Authors:  Duangporn Werawatganon; Narisorn Rakananurak; Sasipim Sallapant; Piyapan Prueksapanich; Kanjana Somanawat; Naruemon Klaikeaw; Rungsun Rerknimitr
Journal:  World J Gastroenterol       Date:  2014-12-28       Impact factor: 5.742

3.  SERPINB13 is a novel RUNX1 target gene.

Authors:  Anita Boyapati; Bing Ren; Dong-Er Zhang
Journal:  Biochem Biophys Res Commun       Date:  2011-06-23       Impact factor: 3.575

4.  Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia.

Authors:  Kim A Boost; Sandra Hoegl; Christian Hofstetter; Michael Flondor; Klaus Stegewerth; Ilka Platacis; Josef Pfeilschifter; Heiko Muhl; Bernhard Zwissler
Journal:  Intensive Care Med       Date:  2007-03-24       Impact factor: 17.440

5.  Normal-range albuminuria does not exclude nephropathy in diabetic children.

Authors:  Jacek Zachwieja; Jolanta Soltysiak; Piotr Fichna; Katarzyna Lipkowska; Witold Stankiewicz; Bogda Skowronska; Pawel Kroll; Maria Lewandowska-Stachowiak
Journal:  Pediatr Nephrol       Date:  2010-02-16       Impact factor: 3.714

6.  IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.

Authors:  Malte Bachmann; Patrick Scheiermann; Lorena Härdle; Josef Pfeilschifter; Heiko Mühl
Journal:  J Biol Chem       Date:  2012-10-24       Impact factor: 5.157

7.  Felodipine downregulates serum interleukin-18 levels in rats with fructose-induced metabolic syndrome.

Authors:  X-P Bi; H-W Tan; S-S Xing; M Zhong; Y Zhang; W Zhang
Journal:  J Endocrinol Invest       Date:  2009-04       Impact factor: 4.256

Review 8.  Necrotizing enterocolitis: a multifactorial disease with no cure.

Authors:  Kareena-L Schnabl; John-E Van Aerde; Alan-Br Thomson; Michael-T Clandinin
Journal:  World J Gastroenterol       Date:  2008-04-14       Impact factor: 5.742

9.  Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels.

Authors:  Tanja Zeller; Tina Haase; Christian Müller; Helene Riess; Denise Lau; Simon Zeller; Jasmin Krause; Jens Baumert; Ole Pless; Josée Dupuis; Philipp S Wild; Medea Eleftheriadis; Melanie Waldenberger; Sonja Zeilinger; Andreas Ziegler; Annette Peters; Laurence Tiret; Carole Proust; Carola Marzi; Thomas Munzel; Konstantin Strauch; Holger Prokisch; Karl J Lackner; Christian Herder; Barbara Thorand; Emilia J Benjamin; Stefan Blankenberg; Wolfgang Koenig; Renate B Schnabel
Journal:  Circ Cardiovasc Genet       Date:  2015-09-11

10.  Role of serum interleukin-18 as a prognostic factor in patients with hepatocellular carcinoma.

Authors:  Pisit Tangkijvanich; Duangporn Thong-Ngam; Varocha Mahachai; Apiradee Theamboonlers; Yong Poovorawan
Journal:  World J Gastroenterol       Date:  2007-08-28       Impact factor: 5.742
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