Literature DB >> 15463786

Molting, enzymes and new targets for chemotherapy of Onchocerca volvulus.

S Lustigman1.   

Abstract

Parasitic nematodes do not multiply in definitive hosts, but they do molt, grow and mature for a certain period after infection, after which they devote their energies almost entirely to egg production. In this review, Sara Lustigman describes key metabolic enzymes that are essential to the development of the larval stages of Onchocerca volvulus in the host, making them potential therapeutic targets.

Entities:  

Year:  1993        PMID： 15463786     DOI： 10.1016/0169-4758(93)90128-3

Source DB:  PubMed          Journal:  Parasitol Today        ISSN： 0169-4758


  5 in total

1.  An ERp60-like protein from the filarial parasite Dirofilaria immitis has both transglutaminase and protein disulfide isomerase activity.

Authors:  R Chandrashekar; N Tsuji; T Morales; V Ozols; K Mehta
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-20       Impact factor: 11.205

2.  Transglutaminase-catalyzed reaction is important for molting of Onchocerca volvulus third-stage larvae.

Authors:  S Lustigman; B Brotman; T Huima; A L Castelhano; R N Singh; K Mehta; A M Prince
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

3.  Tissue localization of collagenase and leucine aminopeptidase in the bovine filarial parasite Setaria cervi.

Authors:  Daya R Pokharel; Reeta Rai; Pankaj Kumar; C M Chaturvedi; Sushma Rathaur
Journal:  Filaria J       Date:  2006-05-22

4.  Protein and antigen profiles of third-stage larvae of Gnathostoma spinigerum assessed with next-generation sequencing transcriptomic information.

Authors:  Kathyleen Nogrado; Tipparat Thiangtrongjit; Poom Adisakwattana; Paron Dekumyoy; Sant Muangnoicharoen; Charin Thawornkuno; Onrapak Reamtong
Journal:  Sci Rep       Date:  2022-04-28       Impact factor: 4.996

5.  A Zinc Metalloprotease nas-33 Is Required for Molting and Survival in Parasitic Nematode Haemonchus contortus.

Authors:  Yan Huang; Jie Wu; Xueqiu Chen; Danni Tong; Jingru Zhou; Fei Wu; Hui Zhang; Yi Yang; Guangxu Ma; Aifang Du
Journal:  Front Cell Dev Biol       Date:  2021-07-13
  5 in total

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