Literature DB >> 15463696

The lipophosphoglycan of Leishmania and macrophage protein kinase C.

A Descoteaux1, S J Turco.   

Abstract

Lipophosphoglycan (LPG), the major cellsurface glycoconjugate of Leishmania promastigotes, is on essential virulence determinant. One feature of LPG resides in its strong inhibitory effect on the activity of purified protein kinase C (PKC). In this article, Albert Descoteaux and Salvatore Turco briefly review the evidence that LPG effectively inhibits PKC activity in the macrophage, and discuss the implication of such inhibition on Leishmania intramacrophoge survival.

Entities:  

Year:  1993        PMID： 15463696     DOI： 10.1016/0169-4758(93)90105-o

Source DB:  PubMed          Journal:  Parasitol Today        ISSN： 0169-4758


  17 in total

1.  Regulation of impaired protein kinase C signaling by chemokines in murine macrophages during visceral leishmaniasis.

Authors:  Ranadhir Dey; Arup Sarkar; Nivedita Majumder; Suchandra Bhattacharyya Majumdar; Kaushik Roychoudhury; Sandip Bhattacharyya; Syamal Roy; Subrata Majumdar
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

2.  Leishmania pifanoi amastigotes avoid macrophage production of superoxide by inducing heme degradation.

Authors:  Nam-Kha Pham; Jennifer Mouriz; Peter E Kima
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

3.  Transbilayer inhibition of protein kinase C by the lipophosphoglycan from Leishmania donovani.

Authors:  J R Giorgione; S J Turco; R M Epand
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

Review 4.  Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies.

Authors:  Kathleen E Sullivan; Hamid Bassiri; Ahmed A Bousfiha; Beatriz T Costa-Carvalho; Alexandra F Freeman; David Hagin; Yu L Lau; Michail S Lionakis; Ileana Moreira; Jorge A Pinto; M Isabel de Moraes-Pinto; Amit Rawat; Shereen M Reda; Saul Oswaldo Lugo Reyes; Mikko Seppänen; Mimi L K Tang
Journal:  J Clin Immunol       Date:  2017-08-07       Impact factor: 8.317

5.  Proteophosphoglycans of Leishmania mexicana. Identification, purification, structural and ultrastructural characterization of the secreted promastigote proteophosphoglycan pPPG2, a stage-specific glycoisoform of amastigote aPPG.

Authors:  C Klein; U Göpfert; N Goehring; Y D Stierhof; T Ilg
Journal:  Biochem J       Date:  1999-12-15       Impact factor: 3.857

6.  Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana.

Authors:  T Ilg
Journal:  EMBO J       Date:  2000-05-02       Impact factor: 11.598

7.  Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction events.

Authors:  S Bhattacharyya; S Ghosh; P L Jhonson; S K Bhattacharya; S Majumdar
Journal:  Infect Immun       Date:  2001-03       Impact factor: 3.441

8.  Leishmania pifanoi proteoglycolipid complex P8 induces macrophage cytokine production through Toll-like receptor 4.

Authors:  Shanta M Whitaker; Maria Colmenares; Karen Goldsmith Pestana; Diane McMahon-Pratt
Journal:  Infect Immun       Date:  2008-02-25       Impact factor: 3.441

9.  Human T-cell activation by 14- and 18-kilodalton nuclear proteins of Leishmania infantum.

Authors:  I Suffia; J F Quaranta; M C Eulalio; B Ferrua; P Marty; Y Le Fichoux; J Kubar
Journal:  Infect Immun       Date:  1995-10       Impact factor: 3.441

10.  Innate immune activation and subversion of Mammalian functions by leishmania lipophosphoglycan.

Authors:  Luis H Franco; Stephen M Beverley; Dario S Zamboni
Journal:  J Parasitol Res       Date:  2012-02-22
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