Non-random host selection by anopheline mosquitoes.

Malaria represents a complex system. Transmission depends on a multitude of factors - of which vector density may not be the most important (see Box 1). The classical Ross-Macdonald model of malaria transmission (Box 2) reveals two dominant factors: the probability that a mosquito will survive long enough for the parasite to develop to its infective stage, and the likelihood that the mosquito will feed on man. An important assumption however, is that all individuals will be at equal risk from mosquito attack. In fact, host-vector contact is far from randomly distributed. In this review, Tom Burkot explains the biological causes of non-random host selection by anopheline vectors, and Chris Dye discusses some of the epidemiological implications of this selection for malaria transmission (Box 3).