Molecular weight separation of very large DNA.

Gel electrophoresis has many applications in parasitology, especially for the separation of enzymes, immunoglobulins and DNA, but the ability to separate molecules based on size is usually restricted to within the upper and lower ranges o f molecular weight. These limitations are particularly evident in mocromolecular DNA electrophoresis, although recent innovations in ogorose gel electrophoresis have substantially reduced these boundaries and are permitting the separation of very large DNA molecules and intact chromosomes of many organisms. In this article, Hugh Dawkins explains these techniques and their principle variants.