Literature DB >> 15462742

Immunopathology of granuloma formation and fibrosis in schistosomiasis.

S M Phillips1, P J Lammie.   

Abstract

In schistosomiasis the deposition of parasite ova within host tissues is the initial event in a complex pathophysiological cascade which is characterized by granuloma formation, and may terminate in fibrosis and related sequelae (Fig. 1). In spite of intensive study, the complex relationship between infection and morbidity remains poorly understood. In this article, Michael Phillips and Patrick Lammie review current concepts of the mechanisms of granuloma formation and its regulation in schistosome infections.

Entities:  

Year:  1986        PMID： 15462742     DOI： 10.1016/0169-4758(86)90123-7

Source DB:  PubMed          Journal:  Parasitol Today        ISSN： 0169-4758


  17 in total

1.  Schistosomal egg antigen-responsive CD8 T-cell population in Schistosoma mansoni-infected BALB/c mice.

Authors:  V Pancré; M Delacre; J Herno; C Auriault
Journal:  Immunology       Date:  1999-12       Impact factor: 7.397

2.  Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni.

Authors:  A Sher; R L Coffman; S Hieny; P Scott; A W Cheever
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

Review 3.  Gastrointestinal manifestations of schistosomiasis.

Authors:  G T Strickland
Journal:  Gut       Date:  1994-10       Impact factor: 23.059

4.  Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection.

Authors:  S A Rezende; V R Oliveira; A M Silva; J B Alves; A M Goes; L F Reis
Journal:  Infect Immun       Date:  1997-08       Impact factor: 3.441

5.  Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells.

Authors:  L R Brunet; E A Sabin; A W Cheever; M A Kopf; E J Pearce
Journal:  Infect Immun       Date:  1999-06       Impact factor: 3.441

6.  Utilization of fractionated soluble egg antigens reveals selectively modulated granulomatous and lymphokine responses during murine schistosomiasis mansoni.

Authors:  N W Lukacs; D L Boros
Journal:  Infect Immun       Date:  1992-08       Impact factor: 3.441

7.  Schistosomiasis and in vitro transdifferentiation of murine peritoneal macrophages into fibroblastic cells.

Authors:  M Godoy; M Geuskens; E A Van Marck; R Borojevic; P Van Gansen
Journal:  Parasitol Res       Date:  1989       Impact factor: 2.289

8.  T-lymphocyte responsiveness in murine schistosomiasis mansoni is dependent upon the adhesion molecules intercellular adhesion molecule-1, lymphocyte function-associated antigen-1, and very late antigen-4.

Authors:  J G Langley; D L Boros
Journal:  Infect Immun       Date:  1995-10       Impact factor: 3.441

9.  Splenic and granuloma T-lymphocyte responses to fractionated soluble egg antigens of Schistosoma mansoni-infected mice.

Authors:  N W Lukacs; D L Boros
Journal:  Infect Immun       Date:  1991-03       Impact factor: 3.441

10.  CD4+ Th2 cell response cytokine production in bacterial meningitis.

Authors:  S Raziuddin; M E el-Awad; A W Telmesani; N E Bilal; M al-Janadi
Journal:  J Clin Immunol       Date:  1995-11       Impact factor: 8.317
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