Literature DB >> 15461912

Preview of new drugs for overactive bladder and incontinence: darifenacin, solifenacin, trospium, and duloxetine.

Richard T Kershen1, Mike Hsieh.   

Abstract

This year, the US Food and Drug Administration will approve four new drugs indicated for the treatment of lower urinary tract dysfunction. Darifenacin, solifenacin, and trospium are antimuscarinic agents aimed at relieving the symptoms of overactive bladder and urge incontinence in men and women. Duloxetine will be the first drug approved for the treatment of female stress urinary incontinence. This article presents current data on the efficacy and tolerability of these new agents and invites the reader to decide whether they offer any potential advantages over existing therapies.

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Year:  2004        PMID： 15461912     DOI： 10.1007/s11934-004-0083-x

Source DB:  PubMed          Journal:  Curr Urol Rep        ISSN： 1527-2737            Impact factor:   2.862


  47 in total

1.  Effects of tolterodine, trospium chloride, and oxybutynin on the central nervous system.

Authors:  A Todorova; B Vonderheid-Guth; W Dimpfel
Journal:  J Clin Pharmacol       Date:  2001-06       Impact factor: 3.126

Review 2.  Trospium chloride: a quaternary amine with unique pharmacologic properties.

Authors:  Raymond W Pak; Steven P Petrou; David R Staskin
Journal:  Curr Urol Rep       Date:  2003-12       Impact factor: 3.092

3.  Effect of 5-HT receptor and adrenoceptor antagonists on micturition in conscious cats.

Authors:  M J Espey; J W Downie; A Fine
Journal:  Eur J Pharmacol       Date:  1992-10-06       Impact factor: 4.432

4.  Effect of trospium chloride on urodynamic parameters in patients with detrusor hyperreflexia due to spinal cord injuries. A multicentre placebo-controlled double-blind trial.

Authors:  M Stöhrer; P Bauer; B M Giannetti; R Richter; H Burgdörfer; G Mürtz
Journal:  Urol Int       Date:  1991       Impact factor: 2.089

5.  Muscarinic cholinergic receptor subtypes in rat sublingual glands.

Authors:  G E Watson; D J Culp
Journal:  Am J Physiol       Date:  1994-02

6.  Pharmacodynamics of anticholinergic agents measured by ambulatory urodynamic monitoring: a study of methodology.

Authors:  D J Rosario; D J Smith; S C Radley; C R Chapple
Journal:  Neurourol Urodyn       Date:  1999       Impact factor: 2.696

Review 7.  Trospium chloride--an effective drug in the treatment of overactive bladder and detrusor hyperreflexia.

Authors:  K Höfner; M Oelke; S Machtens; V Grünewald
Journal:  World J Urol       Date:  2001-11       Impact factor: 4.226

8.  Serotoninergic, noradrenergic, and peptidergic innervation of Onuf's nucleus of normal and transected spinal cords of baboons (Papio papio).

Authors:  N Rajaofetra; J G Passagia; L Marlier; P Poulat; F Pellas; F Sandillon; B Verschuere; D Gouy; M Geffard; A Privat
Journal:  J Comp Neurol       Date:  1992-04-01       Impact factor: 3.215

9.  Duloxetine vs placebo in the treatment of stress urinary incontinence: a four-continent randomized clinical trial.

Authors:  R J Millard; K Moore; R Rencken; I Yalcin; R C Bump
Journal:  BJU Int       Date:  2004-02       Impact factor: 5.588

10.  Trospium chloride versus oxybutynin: a randomized, double-blind, multicentre trial in the treatment of detrusor hyper-reflexia.

Authors:  H Madersbacher; M Stöhrer; R Richter; H Burgdörfer; H J Hachen; G Mürtz
Journal:  Br J Urol       Date:  1995-04
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  8 in total

Review 1.  Improving the tolerability of anticholinergic agents in the treatment of overactive bladder.

Authors:  Roger Dmochowski
Journal:  Drug Saf       Date:  2005       Impact factor: 5.606

2.  Management of urinary incontinence.

Authors:  George A Demaagd; Timothy C Davenport
Journal:  P T       Date:  2012-06

Review 3.  Solifenacin in overactive bladder syndrome.

Authors:  Christopher K Payne
Journal:  Drugs       Date:  2006       Impact factor: 9.546

Review 4.  Current trends in the evaluation and management of female urinary incontinence.

Authors:  Phillip P Smith; Rebecca J McCrery; Rodney A Appell
Journal:  CMAJ       Date:  2006-11-07       Impact factor: 8.262

Review 5.  Stress urinary incontinence in women: diagnosis and medical management.

Authors:  Mark Deutchman; Meghan Wulster-Radcliffe
Journal:  MedGenMed       Date:  2005-12-06

6.  Urodynamic study and quality of life in patients with fibromyalgia and lower urinary tract symptoms.

Authors:  Maíta Poli de Araújo; Alex Carvalho Faria; Claudia Cristina Takano; Emerson de Oliveira; Marair Gracio Ferreira Sartori; Daniel Feldman Pollak; Manoel Joâo Batista Castello Girão
Journal:  Int Urogynecol J Pelvic Floor Dysfunct       Date:  2008-03-04

Review 7.  Female neurogenic vesicourethral dysfunction: evaluation and management.

Authors:  Rebecca J McCrery; Rodney A Appell
Journal:  Curr Urol Rep       Date:  2005-09       Impact factor: 2.862

8.  A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder.

Authors:  Yosuke Nakatani; Michiyuki Suzuki; Masaki Tokunaga; Jun Maeda; Miyuki Sakai; Hiroki Ishihara; Takashi Yoshinaga; Osamu Takenaka; Ming-Rong Zhang; Tetsuya Suhara; Makoto Higuchi
Journal:  PLoS One       Date:  2013-09-23       Impact factor: 3.240
  8 in total

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