Literature DB >> 15461808

Gene-dosage effects in Down syndrome and trisomic mouse models.

Katheleen Gardiner1.   

Abstract

The abnormalities found in human Down syndrome (trisomy 21) have been thought to result from increased expression of genes on chromosome 21 because of their higher gene dosage. Now, several groups have shown this to be generally the case, but some inter-individual variability and other exceptions were found.

Entities:  

Mesh：

Year:  2004        PMID： 15461808      PMCID： PMC545589          DOI： 10.1186/gb-2004-5-10-244

Source DB:  PubMed          Journal:  Genome Biol        ISSN： 1474-7596            Impact factor:   13.583


  16 in total

1.  Analysis of gene expression in the rat hippocampus using Real Time PCR reveals high inter-individual variation in mRNA expression levels.

Authors:  Julieta Alfonso; Guido D Pollevick; Anja Castensson; Elena Jazin; Alberto C C Frasch
Journal:  J Neurosci Res       Date:  2002-01-15       Impact factor: 4.164

2.  Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome.

Authors:  Robert Lyle; Corinne Gehrig; Charlotte Neergaard-Henrichsen; Samuel Deutsch; Stylianos E Antonarakis
Journal:  Genome Res       Date:  2004-07       Impact factor: 9.043

3.  Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.

Authors:  H Sago; E J Carlson; D J Smith; J Kilbridge; E M Rubin; W C Mobley; C J Epstein; T T Huang
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

4.  Evolutionary breakpoints on human chromosome 21.

Authors:  M T Davisson; L J Bechtel; E C Akeson; A Fortna; D Slavov; K Gardiner
Journal:  Genomics       Date:  2001-11       Impact factor: 5.736

5.  Down syndrome phenotypes: the consequences of chromosomal imbalance.

Authors:  J R Korenberg; X N Chen; R Schipper; Z Sun; R Gonsky; S Gerwehr; N Carpenter; C Daumer; P Dignan; C Disteche
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

6.  Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome.

Authors:  Kenji Amano; Haruhiko Sago; Chiharu Uchikawa; Taishi Suzuki; Svetlana E Kotliarova; Nobuyuki Nukina; Charles J Epstein; Kazuhiro Yamakawa
Journal:  Hum Mol Genet       Date:  2004-05-11       Impact factor: 6.150

7.  Genetic analysis of genome-wide variation in human gene expression.

Authors:  Michael Morley; Cliona M Molony; Teresa M Weber; James L Devlin; Kathryn G Ewens; Richard S Spielman; Vivian G Cheung
Journal:  Nature       Date:  2004-07-21       Impact factor: 49.962

8.  Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome.

Authors:  Pascal Kahlem; Marc Sultan; Ralf Herwig; Matthias Steinfath; Daniela Balzereit; Barbara Eppens; Nidhi G Saran; Mathew T Pletcher; Sarah T South; Gail Stetten; Hans Lehrach; Roger H Reeves; Marie-Laure Yaspo
Journal:  Genome Res       Date:  2004-07       Impact factor: 9.043

Review 9.  Segmental trisomy as a mouse model for Down syndrome.

Authors:  M T Davisson; C Schmidt; R H Reeves; N G Irving; E C Akeson; B S Harris; R T Bronson
Journal:  Prog Clin Biol Res       Date:  1993

10.  Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions.

Authors:  Katheleen Gardiner; Andrew Fortna; Lawrence Bechtel; Muriel T Davisson
Journal:  Gene       Date:  2003-10-30       Impact factor: 3.688
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  15 in total

1.  Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade.

Authors:  Matthew G Bartley; Kristin Marquardt; Danielle Kirchhof; Heather M Wilkins; David Patterson; Daniel A Linseman
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

Review 2.  The cognitive phenotype of Down syndrome: insights from intracellular network analysis.

Authors:  Avi Ma'ayan; Katheleen Gardiner; Ravi Iyengar
Journal:  NeuroRx       Date:  2006-07

3.  Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome.

Authors:  Christy M Kelley; Stephen D Ginsberg; Melissa J Alldred; Barbara J Strupp; Elliott J Mufson
Journal:  Dev Neurobiol       Date:  2019-06-09       Impact factor: 3.964

4.  Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes.

Authors:  Jennifer Keck-Wherley; Deepak Grover; Sharmistha Bhattacharyya; Xiufen Xu; Derek Holman; Eric D Lombardini; Ranjana Verma; Roopa Biswas; Zygmunt Galdzicki
Journal:  Dev Neurosci       Date:  2011-10-27       Impact factor: 2.984

Review 5.  Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain.

Authors:  D Allan Butterfield; Fabio Di Domenico; Aaron M Swomley; Elizabeth Head; Marzia Perluigi
Journal:  Biochem J       Date:  2014-10-15       Impact factor: 3.857

6.  Impairment of circulating endothelial progenitors in Down syndrome.

Authors:  Valerio Costa; Linda Sommese; Amelia Casamassimi; Roberta Colicchio; Claudia Angelini; Valentina Marchesano; Lara Milone; Bartolomeo Farzati; Alfonso Giovane; Carmela Fiorito; Monica Rienzo; Marco Picardi; Bice Avallone; Massimiliano Marco Corsi; Berardo Sarubbi; Raffaele Calabrò; Paola Salvatore; Alfredo Ciccodicola; Claudio Napoli
Journal:  BMC Med Genomics       Date:  2010-09-13       Impact factor: 3.063

7.  What can we learn from study of Alzheimer's disease in patients with Down syndrome for early-onset Alzheimer's disease in the general population?

Authors:  Robyn A Wallace; Arthur J Dalton
Journal:  Alzheimers Res Ther       Date:  2011-04-19       Impact factor: 6.982

8.  Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21.

Authors:  Chi-Ming Li; Meirong Guo; Martha Salas; Nicole Schupf; Wayne Silverman; Warren B Zigman; Sameera Husain; Dorothy Warburton; Harshwardhan Thaker; Benjamin Tycko
Journal:  BMC Med Genet       Date:  2006-03-15       Impact factor: 2.103

9.  Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy.

Authors:  Anna Conti; Floriana Fabbrini; Paola D'Agostino; Rosa Negri; Dario Greco; Rita Genesio; Maria D'Armiento; Carlo Olla; Dario Paladini; Mariastella Zannini; Lucio Nitsch
Journal:  BMC Genomics       Date:  2007-08-07       Impact factor: 3.969

10.  Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.

Authors:  Pavel V Belichenko; Alexander M Kleschevnikov; Ann Becker; Grant E Wagner; Larisa V Lysenko; Y Eugene Yu; William C Mobley
Journal:  PLoS One       Date:  2015-07-31       Impact factor: 3.240
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