The diagnostic criteria of Gianotti-Crosti syndrome: are they applicable to children in India?

In order to evaluate the applicability of the diagnostic criteria to children with Gianotti-Crosti syndrome (GCS) in India we retrieved all clinical records of children with a definite diagnosis of this syndrome seen over 30 months in a private dermatology practice. The controls were children for whom Gianotti-Crosti had been suspected but the final diagnosis was not this syndrome, and children in whom it was not suspected but who were diagnosed with any of the differential diagnoses of the syndrome. We documented the presence or absence of the positive and negative clinical features for all patients and controls. The clinical records of 23 children with GCS and 74 controls were retrieved. The three positive clinical features--1) papules or papulovesicles 1-10 mm in diameter on at least three of the following four sites: cheeks, buttocks, extensor surfaces of the forearms, extensor surfaces of legs; 2) being symmetrical; 3) lasting for at least 10 days--were sensitive and positively correlated with GCS. Both negative clinical features--extensive truncal lesions and scaly lesions--are negatively correlated with this syndrome. All 23 children with GCS and none of the controls fulfilled the set of diagnostic criteria. We concluded that the Gianotti-Crosti diagnostic criteria are applicable to affected children in India.