Literature DB >> 1546137

Interaction of moclobemide and tricyclic antidepressants with the tyramine pressor effect in rats.

W Burkard1, F d'Agostini, R Kettler, M Da Prada.   

Abstract

Tyramine at high doses (20 mg/kg) increased arterial blood pressure in freely moving rats. This increase was completely prevented by pretreatment with inhibitors of neuronal membrane carriers for noradrenaline (e.g. desipramine or oxaprotiline). Pretreatment with moclobemide induced a mild potentiation of this tyramine-pressor effect which could also be attenuated dose-dependently by co-administration of oxaprotiline.

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Year:  1992        PMID： 1546137     DOI： 10.1007/bf02246231

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  3 in total

1.  Blood sampling by chronic cannulation technique for reliable measurements of catecholamines and other hormones in plasma of conscious rats.

Authors:  M O Carruba; G B Picotti; P Miodini; W Lotz; M Da Prada
Journal:  J Pharmacol Methods       Date:  1981-06

2.  Some basic aspects of reversible inhibitors of monoamine oxidase-A.

Authors:  M Da Prada; R Kettler; W P Burkard; H P Lorez; W Haefely
Journal:  Acta Psychiatr Scand Suppl       Date:  1990

3.  [Comparison of the new MAO-A inhibitors moclobemide, brofaromine and toloxatone with tranylcypromine in an animal experiment: significance for clinical practice].

Authors:  M Da Prada; H H Keller; R Kettler
Journal:  Psychiatr Prax       Date:  1989-08
  3 in total
  1 in total

Review 1.  A reassessment of the safety profile of monoamine oxidase inhibitors: elucidating tired old tyramine myths.

Authors:  Peter Kenneth Gillman
Journal:  J Neural Transm (Vienna)       Date:  2018-09-25       Impact factor: 3.575
  1 in total

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