OBJECTIVE: The purpose of this paper was to explore the effect of iron and zinc in diet on development of bone in growing rats exposed to lead and observed the change of bone mineral content (BMC) and bone mineral density (BMD). METHODS: The growing rats were fed with diet added with different levels of iron, zinc and lead for 12 weeks. RESULTS: Long-term exposure to lead may inhibit the development of bone and reduce BMC and BMD, it can be improved the weight and length of bone and increased BMC and BMD following the increased in iron and zinc levels in the diets, but the lead level of bone increases. CONCLUSION: Supplementary suitable iron or/and zinc could improve the BMC and BMD, the mechanism of iron and zinc in diets on bone exposed to lead should be further research.
OBJECTIVE: The purpose of this paper was to explore the effect of iron and zinc in diet on development of bone in growing rats exposed to lead and observed the change of bone mineral content (BMC) and bone mineral density (BMD). METHODS: The growing rats were fed with diet added with different levels of iron, zinc and lead for 12 weeks. RESULTS: Long-term exposure to lead may inhibit the development of bone and reduce BMC and BMD, it can be improved the weight and length of bone and increased BMC and BMD following the increased in iron and zinc levels in the diets, but the lead level of bone increases. CONCLUSION: Supplementary suitable iron or/and zinc could improve the BMC and BMD, the mechanism of iron and zinc in diets on bone exposed to lead should be further research.