OBJECTIVE: To investigate the effects of propofol on spontaneous contractions of isolated human pregnant myometrial smooth muscles. METHODS:Twenty isolated human pregnant myometrial muscle strips with rhythmic spontaneous contraction were randomly divided into two groups: control group (n=10) and propofol group (n=10). In propofol group propofol was added cumulatively. The changes of uterine contraction were monitored. RESULTS:Propofol at concentration of 0. 5 microg/ml and 2 microg/ml had no effect on the spontaneous contraction of isolated human pregnant uterine muscles; propofol at concentration of 5 microg/ml and 10 microg/ml could significantly reduce the spontaneous contraction of isolated human pregnant uterine muscles; the higher the concentration was, the more would be the reduction. The effect could be blocked by oxytocin (140 +/- 50) microU/ml. CONCLUSION:Propofol could significantly reduce the spontaneous rhythmic contractions of isolated human pregnant myometrial smooth muscles in concentration-dependent manner. Oxytocin could antagonize the action.
RCT Entities:
OBJECTIVE: To investigate the effects of propofol on spontaneous contractions of isolated human pregnant myometrial smooth muscles. METHODS: Twenty isolated human pregnant myometrial muscle strips with rhythmic spontaneous contraction were randomly divided into two groups: control group (n=10) and propofol group (n=10). In propofol group propofol was added cumulatively. The changes of uterine contraction were monitored. RESULTS:Propofol at concentration of 0. 5 microg/ml and 2 microg/ml had no effect on the spontaneous contraction of isolated human pregnant uterine muscles; propofol at concentration of 5 microg/ml and 10 microg/ml could significantly reduce the spontaneous contraction of isolated human pregnant uterine muscles; the higher the concentration was, the more would be the reduction. The effect could be blocked by oxytocin (140 +/- 50) microU/ml. CONCLUSION:Propofol could significantly reduce the spontaneous rhythmic contractions of isolated human pregnant myometrial smooth muscles in concentration-dependent manner. Oxytocin could antagonize the action.