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Literature DB >> 15459746

Daughter-specific repression of Saccharomyces cerevisiae HO: Ash1 is the commander.

Abstract

The GATA-1-like factor Ash1 is a repressor of the HO gene, which encodes an endonuclease that is responsible for mating-type switching in the yeast Saccharomyces cerevisiae. A multi-step programme, which involves a macromolecular protein complex, the secondary structure of ASH1 mRNA and the cell cytoskeleton, enables Ash1 to asymmetrically localize to the daughter cell nucleus in late anaphase and to repress HO transcription. The resulting Ash1 activity prevents the daughter cell from switching mating type. How does Ash1 inhibit transcription of HO exclusively in the daughter cell? In this review, a speculative model is proposed and discussed. Through its action as a daughter-specific repressor, Ash1 can be considered to be an ancestral regulator of cell fate in eukaryotes.

Entities: Chemical

Mesh：

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Year: 2004 PMID： 15459746 PMCID： PMC1299151 DOI： 10.1038/sj.embor.7400251

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

37 in total

1. Cell cycle-regulated histone acetylation required for expression of the yeast HO gene.

Authors: J E Krebs; M H Kuo; C D Allis; C L Peterson
Journal: Genes Dev Date: 1999-06-01 Impact factor: 11.361

2. The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p.

Authors: P A Takizawa; R D Vale
Journal: Proc Natl Acad Sci U S A Date: 2000-05-09 Impact factor: 11.205

3. Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays.

Authors: K E Neely; A H Hassan; A E Wallberg; D J Steger; B R Cairns; A P Wright; J L Workman
Journal: Mol Cell Date: 1999-10 Impact factor: 17.970

4. Ash1, a daughter cell-specific protein, is required for pseudohyphal growth of Saccharomyces cerevisiae.

Authors: S Chandarlapaty; B Errede
Journal: Mol Cell Biol Date: 1998-05 Impact factor: 4.272

5. Structural elements required for the localization of ASH1 mRNA and of a green fluorescent protein reporter particle in vivo.

Authors: P Chartrand; X H Meng; R H Singer; R M Long
Journal: Curr Biol Date: 1999-03-25 Impact factor: 10.834

6. ASH1 mRNA localization in yeast involves multiple secondary structural elements and Ash1 protein translation.

Authors: I Gonzalez; S B Buonomo; K Nasmyth; U von Ahsen
Journal: Curr Biol Date: 1999-03-25 Impact factor: 10.834

7. Mating type switching in yeast controlled by asymmetric localization of ASH1 mRNA.

Authors: R M Long; R H Singer; X Meng; I Gonzalez; K Nasmyth; R P Jansen
Journal: Science Date: 1997-07-18 Impact factor: 47.728

8. Global role for chromatin remodeling enzymes in mitotic gene expression.

Authors: J E Krebs; C J Fry; M L Samuels; C L Peterson
Journal: Cell Date: 2000-09-01 Impact factor: 41.582

9. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.

Authors: R Visintin; K Craig; E S Hwang; S Prinz; M Tyers; A Amon
Journal: Mol Cell Date: 1998-12 Impact factor: 17.970

10. Localization of ASH1 mRNA particles in living yeast.

Authors: E Bertrand; P Chartrand; M Schaefer; S M Shenoy; R H Singer; R M Long
Journal: Mol Cell Date: 1998-10 Impact factor: 17.970

37 in total

1. Dazl can bind to dynein motor complex and may play a role in transport of specific mRNAs.

Authors: Kyung Ho Lee; Seongju Lee; Byunghyuk Kim; Sunghoe Chang; Soo Woong Kim; Jae-Seung Paick; Kunsoo Rhee
Journal: EMBO J Date: 2006-08-31 Impact factor: 11.598

2. SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor.

Authors: Qingquan Liu; Brett Larsen; Marketa Ricicova; Stephen Orlicky; Hille Tekotte; Xiaojing Tang; Karen Craig; Adam Quiring; Thierry Le Bihan; Carl Hansen; Frank Sicheri; Mike Tyers
Journal: Mol Cell Biol Date: 2010-11-22 Impact factor: 4.272

Daughter-specific repression of Saccharomyces cerevisiae HO: Ash1 is the commander.

1. Cell cycle-regulated histone acetylation required for expression of the yeast HO gene.

2. The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p.

3. Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays.

4. Ash1, a daughter cell-specific protein, is required for pseudohyphal growth of Saccharomyces cerevisiae.

5. Structural elements required for the localization of ASH1 mRNA and of a green fluorescent protein reporter particle in vivo.

6. ASH1 mRNA localization in yeast involves multiple secondary structural elements and Ash1 protein translation.

7. Mating type switching in yeast controlled by asymmetric localization of ASH1 mRNA.

8. Global role for chromatin remodeling enzymes in mitotic gene expression.

9. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.

10. Localization of ASH1 mRNA particles in living yeast.

1. Dazl can bind to dynein motor complex and may play a role in transport of specific mRNAs.

2. SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor.

3. Essential features of the class V myosin from budding yeast for ASH1 mRNA transport.

Review 4. Topology and control of the cell-cycle-regulated transcriptional circuitry.

5. Creating memories of transcription.

Review 6. Here, there, everywhere. mRNA localization in budding yeast.

7. Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA.

8. Actin-mediated delivery of astral microtubules instructs Kar9p asymmetric loading to the bud-ward spindle pole.

9. Daughter-specific transcription factors regulate cell size control in budding yeast.

10. The Relationship between Dendritic Branch Dynamics and CPEB-Labeled RNP Granules Captured in Vivo.