Maryam Asgari1, Emily White, Mary-Margaret Chren. 1. Division of Dermatology, University of Washington Medical Center, Seattle, Washington 98195, USA. masgari@u.washington.edu
Abstract
BACKGROUND: Nonsteroidal anti-inflammatory drugs are widely reported to inhibit carcinogenesis. OBJECTIVE: The objective was to review the literature on nonsteroidal anti-inflammatory drugs in the prevention and treatment of cancer as it pertains to cutaneous squamous cell carcinoma. METHODS: We searched MEDLINE and performed a review of all published data on nonsteroidal anti-inflammatory drugs and cutaneous oncogenesis. RESULTS: In vitro and animal data strongly suggest a role for cyclooxygenase-2 in the formation of actinic keratoses and squamous cell carcinomas. Further observational studies and clinical trials are needed to assess their putative role in chemoprevention. CONCLUSIONS: Nonsteroidal anti-inflammatory drugs have activity against squamous cell carcinomas in vitro and in animal models, as well as in precursor lesions of squamous cell carcinomas. Human trials using selective cyclooxygenase-2 inhibitors are currently in progress and should offer exciting information regarding the chemopreventative function of nonsteroidal anti-inflammatory drugs.
BACKGROUND: Nonsteroidal anti-inflammatory drugs are widely reported to inhibit carcinogenesis. OBJECTIVE: The objective was to review the literature on nonsteroidal anti-inflammatory drugs in the prevention and treatment of cancer as it pertains to cutaneous squamous cell carcinoma. METHODS: We searched MEDLINE and performed a review of all published data on nonsteroidal anti-inflammatory drugs and cutaneous oncogenesis. RESULTS: In vitro and animal data strongly suggest a role for cyclooxygenase-2 in the formation of actinic keratoses and squamous cell carcinomas. Further observational studies and clinical trials are needed to assess their putative role in chemoprevention. CONCLUSIONS: Nonsteroidal anti-inflammatory drugs have activity against squamous cell carcinomas in vitro and in animal models, as well as in precursor lesions of squamous cell carcinomas. Human trials using selective cyclooxygenase-2 inhibitors are currently in progress and should offer exciting information regarding the chemopreventative function of nonsteroidal anti-inflammatory drugs.
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Authors: Jean Y Tang; Michelle Aszterbaum; Mohammad Athar; Franco Barsanti; Carol Cappola; Nini Estevez; Jennifer Hebert; Jimmy Hwang; Yefim Khaimskiy; Arianna Kim; Ying Lu; Po-Lin So; Xiuwei Tang; Michael A Kohn; Charles E McCulloch; Levy Kopelovich; David R Bickers; Ervin H Epstein Journal: Cancer Prev Res (Phila) Date: 2010-01
Authors: Maryam M Asgari; Jimmy T Efird; E Margaret Warton; Gary D Friedman Journal: Int J Environ Res Public Health Date: 2010-02-03 Impact factor: 3.390