| Literature DB >> 15457342 |
Carla M de Souza1, Laurence Morel, Wafa H K Cabrera, Nancy Starobinas, Orlando G Ribeiro, Maria Siqueira, Olga M Ibañez, Marcelo De Franco.
Abstract
Two mouse lines were produced by bidirectional selection according to the high (HIII) or low (LIII) antibody responsiveness against Salmonella flagellar antigens (Selection III). In the present work we conducted a genomewide scan to map the quantitative trait loci (QTL) involved in the antibody response regulation in these selected mice. HIII and LIII genomes were screened with microsatellite markers and those found polymorphic between the lines (146) were used for linkage analysis in F2 (HIII x LIII) intercross. Simple interval mapping analysis was performed using Mapmanager QTX software. Three highly significant QTL linked to antibody production against Salmonella flagellar antigens have been demonstrated in Chromosomes 3, 8, and 9. HIII and LIII lines differ in the resistance to several diseases, therefore, the relevance of these QTL with the genetic factors involved in infections, autoimmunity, and neoplastic disease progression is discussed.Entities:
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Year: 2004 PMID： 15457342 DOI： 10.1007/s00335-004-2378-0
Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957