Literature DB >> 1545701

Significance of anthraquinone formation resulting from the cloning of actinorhodin genes in heterologous streptomycetes.

W R Strohl1, N C Connors.   

Abstract

This review explores the underlying biochemical and genetic principles leading to the formation of hybrid anthraquinones by recombinant anthracycline-producing streptomycetes transformed with genes encoding the early steps in actinorhodin biosynthesis. Experiments indicate that simple aromatic polyketides are probably synthesized using very similar mechanisms, allowing for the interspecies cloning of polyketide synthase genes for the potential production of novel aromatic polyketide structures.

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Year:  1992        PMID： 1545701     DOI： 10.1111/j.1365-2958.1992.tb01995.x

Source DB:  PubMed          Journal:  Mol Microbiol        ISSN： 0950-382X            Impact factor:   3.501


  7 in total

1.  Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.

Authors:  M L Dickens; J Ye; W R Strohl
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

2.  Nucleotide sequence analysis of five putative Streptomyces griseus genes, one of which complements an early function in daunorubicin biosynthesis that is linked to a putative gene cluster involved in TDP-daunosamine formation.

Authors:  H Krügel; G Schumann; F Hänel; G Fiedler
Journal:  Mol Gen Genet       Date:  1993-10

3.  In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA.

Authors:  M L Dickens; N D Priestley; W R Strohl
Journal:  J Bacteriol       Date:  1997-04       Impact factor: 3.490

4.  Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.

Authors:  J Ye; M L Dickens; R Plater; Y Li; J Lawrence; W R Strohl
Journal:  J Bacteriol       Date:  1994-10       Impact factor: 3.490

5.  Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis.

Authors:  V B Rajgarhia; W R Strohl
Journal:  J Bacteriol       Date:  1997-04       Impact factor: 3.490

6.  Heterologous expression of an engineered biosynthetic pathway: functional dissection of type II polyketide synthase components in Streptomyces species.

Authors:  E S Kim; K D Cramer; A L Shreve; D H Sherman
Journal:  J Bacteriol       Date:  1995-03       Impact factor: 3.490

7.  Sulfane sulfur-activated actinorhodin production and sporulation is maintained by a natural gene circuit in Streptomyces coelicolor.

Authors:  Ting Lu; Qun Cao; Xiuhua Pang; Yongzhen Xia; Luying Xun; Huaiwei Liu
Journal:  Microb Biotechnol       Date:  2020-08-09       Impact factor: 5.813
  7 in total

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